Department of Pediatric Neuroscience, Catholic University of Rome, Rome, Italy.
Neurorehabil Neural Repair. 2011 May;25(4):386-90. doi: 10.1177/1545968310395601. Epub 2011 Feb 22.
Spontaneous visual improvement in people with an optic glioma (OG) of the anterior or retrochiasmatic optic pathways is rare.
To evaluate the effects on visual function of nerve growth factor (NGF) eye drop administration in a patient with severe visual impairment due to a low-grade OG.
A 45-year-old woman with OG and long-standing optic nerve atrophy was assessed before and after 2 NGF treatment courses. The drug used was 2.5S murine NGF. One milligram of NGF, diluted in saline solution, was administered onto the conjunctiva of both eyes for 10 consecutive days 3 times a day for each treatment. The follow-up was performed by clinical, neuroradiologic, and electrophysiological tests (electroretinogram and visual evoked potentials [VEPs]) at the end of each treatment and 30 and 60 days later.
A repeated subjective and objective improvement of visual function (>3 lines visual acuity; >40° visual field; >50% VEP amplitude increase, Wilcoxon test P < .01) was recorded after NGF treatment. These measures tended to deteriorate toward baseline values 60 days from the end of each NGF treatment. No ocular or systemic side effects were observed throughout treatment.
Conjunctival NGF may be a beneficial adjunct therapy for visual loss in patients with OG, possibly exerting its effects on residual viable optic pathways.
视神经胶质瘤（OG）在前视路或视交叉后发生时，患者的视力自发改善较为罕见。
评估神经生长因子（NGF）滴眼剂对低级别 OG 导致严重视力损害患者视觉功能的影响。
对一名视神经萎缩伴 OG 的 45 岁女性患者，在接受 2 个 NGF 疗程前后进行评估。使用的药物是 2.5S 鼠源性 NGF。1mg 的 NGF 溶于生理盐水，每日 3 次，每次 10 滴，连续滴眼 10 天。在每个疗程结束时以及之后 30 天和 60 天，通过临床、神经影像学和电生理测试（视网膜电图和视觉诱发电位[VEPs]）进行随访。
在 NGF 治疗后，记录到视觉功能的重复主观和客观改善（视力提高>3 行；视野扩大>40°；VEP 振幅增加>50%，Wilcoxon 检验 P<0.01）。这些指标在每个 NGF 治疗结束后 60 天趋于基线值恶化。在整个治疗过程中，未观察到眼或全身不良反应。
结膜 NGF 可能是 OG 患者视力丧失的有益辅助治疗方法，可能对残留的存活视神经通路发挥作用。
