四氯化锡促进的新型他克林类似物的一锅合成。
Tin (IV) chloride-promoted one-pot synthesis of novel tacrine analogues.
机构信息
College of Pharmaceutical and Chemical Engineering, Taizhou University, Linhai 317000, China.
出版信息
Molecules. 2011 Feb 22;16(2):1878-87. doi: 10.3390/molecules16021878.
Abstract
A facile synthesis of potential acetylcholinesterase (AChE) inhibitors, the tacrine analogues 3a-p, has been accomplished by direct cyclocondensation of 1-aryl-4-cyano-5-aminopyrazole with β-ketoesters using tin(IV) chloride as catalyst. The structures of all the compounds have been confirmed by IR, ¹H- and ¹³C-NMR.
摘要
通过使用四氯化锡作为催化剂，直接缩合 1-芳基-4-氰基-5-氨基吡唑与β-酮酯，简便地合成了潜在的乙酰胆碱酯酶 (AChE) 抑制剂他克林类似物 3a-p。所有化合物的结构均通过 IR、1H-NMR 和 13C-NMR 得到确认。
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