Section of Psychiatry and Psychotherapy, Department of General and Social Psychiatry, Innsbruck Medical University, Innsbruck, Austria.
J Neural Transm (Vienna). 2011 May;118(5):663-72. doi: 10.1007/s00702-011-0599-4. Epub 2011 Feb 23.
An association between plasma Amyloid beta peptides (Aβ) with blood lipids was reported in cross-sectional studies. The present study examined the 5-year prospective association of atherosclerotic risk factors with plasma Aβ42 in 440 elderly persons without both Alzheimer's disease (AD) or mild cognitive impairment (MCI) at baseline. Persons in the highest tertile of total cholesterol (TC) or LDL-C at baseline showed low plasma Aβ42 at 5 years. Regression analysis confirmed TC and LDL-C as negative predictors of Aβ42 (p = 0.001). An increase over 5 years of HDL-C was a negative predictor and the presence of an APOE ε4 allele was a positive predictor for decrease of Aβ42 in converters to MCI. In converters to AD, increase of both TC and of HbA1c were positive predictors of Aβ42 levels at 5 years. Analysis of covariance showed a positive association between Δ-TC, Δ-LDL-C, Δ-HbA1c, and levels of Aβ42 at 5 years (p = 0.006; 0.013 and 0.027 resp.) in converters to AD independently on lipid-lowering treatment. The association of vascular risk factors TC, LDL-C, and HbA1c with higher Aβ42 levels might, after confirmation in other cohorts, influence the development of lifestyle interventions concerning plasma Aβ42 and AD.
在横断面研究中报道了血浆淀粉样蛋白β肽（Aβ）与血脂之间的关联。本研究在基线时无阿尔茨海默病（AD）或轻度认知障碍（MCI）的 440 名老年人中，检查了 5 年前瞻性动脉粥样硬化危险因素与血浆 Aβ42 的关系。基线时总胆固醇（TC）或 LDL-C 最高三分位的人在 5 年内表现出低血浆 Aβ42。回归分析证实 TC 和 LDL-C 是 Aβ42 的负预测因子（p = 0.001）。5 年内 HDL-C 的升高是负预测因子，APOE ε4 等位基因的存在是向 MCI 转化者 Aβ42 减少的正预测因子。在向 AD 转化者中，TC 和 HbA1c 的增加均为 5 年后 Aβ42 水平的正预测因子。协方差分析显示，在向 AD 转化者中，Δ-TC、Δ-LDL-C、Δ-HbA1c 与 5 年后 Aβ42 水平呈正相关（p = 0.006；0.013 和 0.027 分别），独立于降脂治疗。血管危险因素 TC、LDL-C 和 HbA1c 与较高 Aβ42 水平的关联，如果在其他队列中得到证实，可能会影响有关血浆 Aβ42 和 AD 的生活方式干预的发展。
