Benzel E C, Hoffpauir G M, Thomas M M, Beal J A, Lancon J A, Kesterson L
Division of Neurosurgery, University of New Mexico School of Medicine, Albuquerque 87131.
J Spinal Disord. 1990 Dec;3(4):339-44.
A study of the dose-response effects of naloxone and methylprednisolone after rat ventral spinal cord injury is presented. The spinal cord injury model used herein is unique in that it results in a ventral compression of the spinal cord without the need for a prior laminectomy. This allows for a close approximation of the human clinicopathological situation. There was a statistically significant positive effect on neurological outcome with a naloxone dose of 2.5 mg/kg, whereas higher and lower doses yielded little or no influence on outcome. Methylprednisolone was observed to offer similar results. These results, however, did not achieve statistical significance. The early administration of moderately high doses (45-60 mg/kg), however, offered the best results. The responses to the treatment regimens presented here offer hope for spinal cord injury victims. The observed dose-response relationships indicate that erroneous conclusions may arise from studies using inappropriate doses of narcotic antagonists, as well as other drugs.
本文介绍了一项关于大鼠脊髓腹侧损伤后纳洛酮和甲基强的松龙剂量反应效应的研究。本文所使用的脊髓损伤模型的独特之处在于，它会导致脊髓腹侧受压，而无需事先进行椎板切除术。这使得该模型能非常接近人类临床病理情况。纳洛酮剂量为2.5mg/kg时，对神经功能结果有统计学上显著的积极影响，而更高和更低剂量对结果几乎没有影响或没有影响。观察到甲基强的松龙也有类似结果。然而，这些结果没有达到统计学显著性。不过，早期给予中等高剂量（45 - 60mg/kg）产生的效果最佳。此处呈现的治疗方案反应为脊髓损伤受害者带来了希望。观察到的剂量反应关系表明，使用不适当剂量的麻醉拮抗剂以及其他药物进行研究会得出错误结论。
