通过 Henry 反应构建季立体中心：规避取代基乙二醛的通常反应性。
The construction of quaternary stereocenters by the Henry reaction: circumventing the usual reactivity of substituted glyoxals.
机构信息
Departament de Química Orgànica, Facultat de Química, Universitat de València, C/Dr. Moliner 50, Burjassot (València), Spain.
出版信息
Chemistry. 2011 Mar 21;17(13):3768-73. doi: 10.1002/chem.201002888. Epub 2011 Feb 23.
PMID:21344519
Abstract
The enantioselective Henry reaction between alkyl- and arylglyoxal hydrates and nitromethane catalyzed by Cu(II)-iminopyridine complexes takes place regioselectively on the ketone carbonyl group to give chiral tertiary nitroaldols with high functional group density and enantiomeric excesses of up to 96 %. Both aromatic and aliphatic glyoxals are suitable substrates for this reaction.
摘要
手性铜(II)-异噁唑啉配合物催化的醛酮与硝基甲烷的Henry 反应具有区域选择性，在手性仲硝基醇的合成中具有较高的应用价值。
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