Ghoshal D, Barua A K, Roy S K, Bhattacharrya H
Department of Chemistry, Bose Institute, Calcutta, India.
Nutrition. 1990 Mar-Apr;6(2):153-7.
Vaccine failure attributable to immunodeficiency is common in stressed individuals. During vitamin-B complex and ascorbic acid malnutrition in experimental animals, vaccine failure is accounted for by the atrophy of the immunocompetent organs. In an attempt to improve immunocompetence, a bioimmunomodulator obtained from the supernatant fluid from cultured normal bone-marrow cells was injected following immunization into young animals receiving a diet deficient in vitamins B and C. This treatment improved the immunosurveillence of mice and rats approximately 3 to 4 fold. Peculiarly, this factor failed to evoke immunostimulation in normal immunized animals, probably because of a suppressing mechanism.
免疫缺陷导致的疫苗失效在应激个体中很常见。在实验动物出现复合维生素B和抗坏血酸营养不良期间，疫苗失效是由免疫活性器官萎缩所致。为了提高免疫能力，在给缺乏维生素B和C饮食的幼龄动物免疫后，注射了一种从培养的正常骨髓细胞上清液中获得的生物免疫调节剂。这种处理使小鼠和大鼠的免疫监视能力提高了约3至4倍。奇怪的是，该因子在正常免疫动物中未能引发免疫刺激，可能是由于一种抑制机制。
