玻璃纤维暴露与人类呼吸系统癌症风险：自 2001 年 IARC 重新评估以来，缺乏证据的情况依然存在。
Fiber glass exposure and human respiratory system cancer risk: lack of evidence persists since 2001 IARC re-evaluation.
机构信息
Center for Occupational Biostatistics and Epidemiology, Department of Biostatistics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15261, USA.
出版信息
Regul Toxicol Pharmacol. 2011 Jun;60(1):84-92. doi: 10.1016/j.yrtph.2011.02.009. Epub 2011 Feb 21.
OBJECTIVE
To determine whether IARC's 2001 decision to downgrade the classification of insulation glass wool from Group 2B to Group 3 remains valid in light of epidemiological evidence reported after 2001.
METHODS
We performed a systematic review of epidemiological evidence regarding respiratory cancer risks in relation to man-made vitreous fiber (MMVF) exposure before and after the 2001 IARC re-evaluation with focus on glass wool exposure and respiratory system cancer.
RESULTS
Since 2001, three new community-based, case-control studies, two detailed analyses of existing cohort studies and two reviews/meta-analyses were published. These studies revealed no consistent evidence of an increased respiratory system cancer risk in relation to glass wool exposure.
CONCLUSIONS
From our evaluation of the epidemiological evidence published since 2001, we conclude that IARC's 2001 decision to downgrade insulation glass wool from Group 2B to Group 3 remains valid.
目的
鉴于 2001 年后报告的流行病学证据，确定 IARC 将绝缘玻璃棉的分类从 2B 组降级为 3 组的 2001 年决定是否仍然有效。
方法
我们对 2001 年 IARC 重新评估前后有关人造玻璃纤维（MMVF）暴露与呼吸道癌症风险的流行病学证据进行了系统评价，重点关注玻璃棉暴露和呼吸道系统癌症。
结果
自 2001 年以来，发表了三项新的基于社区的病例对照研究、两项对现有队列研究的详细分析以及两项综述/荟萃分析。这些研究没有一致的证据表明玻璃棉暴露与呼吸系统癌症风险增加有关。
结论
从我们对 2001 年以来发表的流行病学证据的评估来看，我们得出结论，IARC 将绝缘玻璃棉从 2B 组降级为 3 组的 2001 年决定仍然有效。
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