Tikka Christina, Verbeek Jos H, Kateman Erik, Morata Thais C, Dreschler Wouter A, Ferrite Silvia
Cochrane Work Review Group, Finnish Institute of Occupational Health, PO Box 310, Kuopio, Finland, 70101.
Cochrane Database Syst Rev. 2017 Jul 7;7(7):CD006396. doi: 10.1002/14651858.CD006396.pub4.
This is the second update of a Cochrane Review originally published in 2009. Millions of workers worldwide are exposed to noise levels that increase their risk of hearing disorders. There is uncertainty about the effectiveness of hearing loss prevention interventions.
To assess the effectiveness of non-pharmaceutical interventions for preventing occupational noise exposure or occupational hearing loss compared to no intervention or alternative interventions.
We searched the CENTRAL; PubMed; Embase; CINAHL; Web of Science; BIOSIS Previews; Cambridge Scientific Abstracts; and OSH UPDATE to 3 October 2016.
We included randomised controlled trials (RCT), controlled before-after studies (CBA) and interrupted time-series (ITS) of non-clinical interventions under field conditions among workers to prevent or reduce noise exposure and hearing loss. We also collected uncontrolled case studies of engineering controls about the effect on noise exposure.
Two authors independently assessed study eligibility and risk of bias and extracted data. We categorised interventions as engineering controls, administrative controls, personal hearing protection devices, and hearing surveillance.
We included 29 studies. One study evaluated legislation to reduce noise exposure in a 12-year time-series analysis but there were no controlled studies on engineering controls for noise exposure. Eleven studies with 3725 participants evaluated effects of personal hearing protection devices and 17 studies with 84,028 participants evaluated effects of hearing loss prevention programmes (HLPPs). Effects on noise exposure Engineering interventions following legislationOne ITS study found that new legislation in the mining industry reduced the median personal noise exposure dose in underground coal mining by 27.7 percentage points (95% confidence interval (CI) -36.1 to -19.3 percentage points) immediately after the implementation of stricter legislation. This roughly translates to a 4.5 dB(A) decrease in noise level. The intervention was associated with a favourable but statistically non-significant downward trend in time of the noise dose of -2.1 percentage points per year (95% CI -4.9 to 0.7, 4 year follow-up, very low-quality evidence). Engineering intervention case studiesWe found 12 studies that described 107 uncontrolled case studies of immediate reductions in noise levels of machinery ranging from 11.1 to 19.7 dB(A) as a result of purchasing new equipment, segregating noise sources or installing panels or curtains around sources. However, the studies lacked long-term follow-up and dose measurements of workers, and we did not use these studies for our conclusions. Hearing protection devicesIn general hearing protection devices reduced noise exposure on average by about 20 dB(A) in one RCT and three CBAs (57 participants, low-quality evidence). Two RCTs showed that, with instructions for insertion, the attenuation of noise by earplugs was 8.59 dB better (95% CI 6.92 dB to 10.25 dB) compared to no instruction (2 RCTs, 140 participants, moderate-quality evidence). Administrative controls: information and noise exposure feedbackOn-site training sessions did not have an effect on personal noise-exposure levels compared to information only in one cluster-RCT after four months' follow-up (mean difference (MD) 0.14 dB; 95% CI -2.66 to 2.38). Another arm of the same study found that personal noise exposure information had no effect on noise levels (MD 0.30 dB(A), 95% CI -2.31 to 2.91) compared to no such information (176 participants, low-quality evidence). Effects on hearing loss Hearing protection devicesIn two studies the authors compared the effect of different devices on temporary threshold shifts at short-term follow-up but reported insufficient data for analysis. In two CBA studies the authors found no difference in hearing loss from noise exposure above 89 dB(A) between muffs and earplugs at long-term follow-up (OR 0.8, 95% CI 0.63 to 1.03 ), very low-quality evidence). Authors of another CBA study found that wearing hearing protection more often resulted in less hearing loss at very long-term follow-up (very low-quality evidence). Combination of interventions: hearing loss prevention programmesOne cluster-RCT found no difference in hearing loss at three- or 16-year follow-up between an intensive HLPP for agricultural students and audiometry only. One CBA study found no reduction of the rate of hearing loss (MD -0.82 dB per year (95% CI -1.86 to 0.22) for a HLPP that provided regular personal noise exposure information compared to a programme without this information.There was very-low-quality evidence in four very long-term studies, that better use of hearing protection devices as part of a HLPP decreased the risk of hearing loss compared to less well used hearing protection in HLPPs (OR 0.40, 95% CI 0.23 to 0.69). Other aspects of the HLPP such as training and education of workers or engineering controls did not show a similar effect.In three long-term CBA studies, workers in a HLPP had a statistically non-significant 1.8 dB (95% CI -0.6 to 4.2) greater hearing loss at 4 kHz than non-exposed workers and the confidence interval includes the 4.2 dB which is the level of hearing loss resulting from 5 years of exposure to 85 dB(A). In addition, of three other CBA studies that could not be included in the meta-analysis, two showed an increased risk of hearing loss in spite of the protection of a HLPP compared to non-exposed workers and one CBA did not.
AUTHORS' CONCLUSIONS: There is very low-quality evidence that implementation of stricter legislation can reduce noise levels in workplaces. Controlled studies of other engineering control interventions in the field have not been conducted. There is moderate-quality evidence that training of proper insertion of earplugs significantly reduces noise exposure at short-term follow-up but long-term follow-up is still needed.There is very low-quality evidence that the better use of hearing protection devices as part of HLPPs reduces the risk of hearing loss, whereas for other programme components of HLPPs we did not find such an effect. The absence of conclusive evidence should not be interpreted as evidence of lack of effectiveness. Rather, it means that further research is very likely to have an important impact.
这是对2009年首次发表的Cochrane系统评价的第二次更新。全球数以百万计的工人暴露于会增加其听力障碍风险的噪声水平下。听力损失预防干预措施的有效性存在不确定性。
评估与不干预或其他干预措施相比,非药物干预措施预防职业性噪声暴露或职业性听力损失的有效性。
我们检索了截至2016年10月3日的Cochrane系统评价数据库(CENTRAL)、PubMed、Embase、护理学与健康领域数据库(CINAHL)、科学引文索引(Web of Science)、生物学文摘数据库(BIOSIS Previews)、剑桥科学文摘数据库(Cambridge Scientific Abstracts)以及职业安全与卫生更新数据库(OSH UPDATE)。
我们纳入了现场条件下工人中预防或减少噪声暴露和听力损失的非临床干预措施的随机对照试验(RCT)、前后对照研究(CBA)和中断时间序列(ITS)研究。我们还收集了关于工程控制对噪声暴露影响的非对照案例研究。
两位作者独立评估研究的纳入资格和偏倚风险并提取数据。我们将干预措施分为工程控制、行政控制、个人听力保护设备和听力监测。
我们纳入了29项研究。一项研究在一项为期12年的时间序列分析中评估了减少噪声暴露的立法,但没有关于噪声暴露工程控制的对照研究。11项研究(3725名参与者)评估了个人听力保护设备的效果,17项研究(84,028名参与者)评估了听力损失预防计划(HLPPs)的效果。对噪声暴露的影响 立法后的工程干预 一项ITS研究发现,采矿业的新立法在实施更严格的立法后,立即将地下煤矿开采中的个人噪声暴露剂量中位数降低了27.7个百分点(95%置信区间(CI)-36.1至-19.3个百分点)。这大致相当于噪声水平降低了4.5 dB(A)。该干预措施与噪声剂量随时间呈有利但无统计学意义的下降趋势相关,每年下降-2.1个百分点(95% CI -4.9至0.7,4年随访,极低质量证据)。工程干预案例研究 我们发现12项研究描述了107项非对照案例研究,这些研究表明,由于购买新设备、隔离噪声源或在声源周围安装面板或窗帘,机器的噪声水平立即降低了11.1至19.7 dB(A)。然而,这些研究缺乏对工人的长期随访和剂量测量,我们未将这些研究用于得出结论。听力保护设备 总体而言,在一项RCT和三项CBA研究(57名参与者,低质量证据)中,听力保护设备平均将噪声暴露降低了约20 dB(A)。两项RCT表明,有插入说明时,耳塞对噪声的衰减比无说明时好8.59 dB(95% CI 6.92 dB至10.25 dB)(2项RCT,140名参与者,中等质量证据)。行政控制:信息与噪声暴露反馈 在一项整群RCT中,经过四个月的随访,与仅提供信息相比,现场培训课程对个人噪声暴露水平没有影响(平均差(MD)0.1 dB;95% CI -2.66至2.38)。同一研究的另一组发现,与不提供此类信息相比,个人噪声暴露信息对噪声水平没有影响(MD 0.30 dB(A),95% CI -2.31至2.91)(176名参与者,低质量证据)。对听力损失的影响 听力保护设备 在两项研究中,作者比较了不同设备在短期随访时对临时阈移的影响,但报告的数据不足以进行分析。在两项CBA研究中,作者发现在长期随访中,对于暴露于89 dB(A)以上噪声的情况,耳罩和耳塞导致的听力损失没有差异(比值比(OR)0.8,95% CI 0.63至1.03),极低质量证据)。另一项CBA研究的作者发现,在非常长期的随访中,如果更频繁地佩戴听力保护设备,听力损失会更少(极低质量证据)。干预措施的组合:听力损失预防计划 一项整群RCT发现,在三年或十六年随访时,针对农业学生的强化HLPP与仅进行听力测定相比,听力损失没有差异。一项CBA研究发现,与不提供定期个人噪声暴露信息的计划相比,提供定期个人噪声暴露信息的HLPP并没有降低听力损失率(MD -0.82 dB/年(95% CI -1.86至0.22))。在四项非常长期的研究中有极低质量证据表明,作为HLPP的一部分,更好地使用听力保护设备与在HLPP中使用较少的听力保护设备相比,可降低听力损失风险(OR 0.40,95% CI 0.23至0.69)。HLPP的其他方面,如对工人的培训和教育或工程控制,未显示出类似效果。在三项长期CBA研究中,参加HLPP的工人在4 kHz时的听力损失比未暴露的工人高1.8 dB(95% CI -0.6至4.2),差异无统计学意义,且置信区间包含了因暴露于五年85 dB(A)而导致的4.2 dB听力损失水平。此外,在另外三项无法纳入荟萃分析的CBA研究中,两项研究显示,尽管有HLPP的保护,但与未暴露的工人相比,听力损失风险增加,一项CBA研究则未显示出这种情况。
有极低质量证据表明实施更严格的立法可降低工作场所的噪声水平。尚未开展关于现场其他工程控制干预措施的对照研究。有中等质量证据表明,耳塞正确佩戴方法的培训在短期随访时可显著降低噪声暴露,但仍需要长期随访。有极低质量证据表明,作为HLPP的一部分,更好地使用听力保护设备可降低听力损失风险,而对于HLPP的其他计划组成部分,我们未发现这种效果。缺乏确凿证据不应被解释为缺乏有效性的证据。相反,这意味着进一步的研究很可能会产生重要影响。