Faculty of Clinical Engineering Technology, School of Health Sciences, Fujita Health University, Kutsukake-cho, Toyoake, Japan.
Blood Purif. 2011;32(1):57-62. doi: 10.1159/000322624. Epub 2011 Feb 24.
BACKGROUND/AIMS: Rapid removal of plasma amyloid-β (Aβ) by blood purification may serve as a peripheral Aβ sink from the brain for Alzheimer's disease therapy. We investigated the reduction of plasma Aβ during hemodialysis and cognitive states.
Aβ concentrations and Mini-Mental State Examinations (MMSE) were investigated in 37 hemodialysis patients (68.9 ± 4.1 years).
The dialyzers effectively removed Aβ(1-40) and Aβ(1-42), 63.9 ± 14.4 and 51.6 ± 17.0% at 4 h dialysis, resulting in the reduction of Aβs in whole-body circulation by 51.1 ± 8.9 and 32.7 ± 12.0%, respectively. Although the plasma Aβs before dialysis (750.8 ± 171.3 pg/ml for Aβ(1-40)) were higher than those reported for Alzheimer's disease patients, the cognitive states of hemodialysis patients were relatively normal, especially of longer dialysis vintages.
Dialyzers effectively reduced Aβs in whole-body circulation. Repeated rapid decrease of plasma Aβs might maintain cognitive state.
背景/目的：通过血液净化快速清除血浆中的淀粉样蛋白-β（Aβ）可能成为阿尔茨海默病治疗中大脑的外周 Aβ清除途径。我们研究了血液透析过程中 Aβ 的减少及其与认知状态的关系。
我们对 37 名血液透析患者（68.9±4.1 岁）进行了 Aβ 浓度和简易精神状态检查（MMSE）的检测。
4 小时透析时，透析器有效去除 Aβ（1-40）和 Aβ（1-42），分别为 63.9±14.4%和 51.6±17.0%，导致全身循环中的 Aβ 减少 51.1±8.9%和 32.7±12.0%。尽管血液透析患者的血浆 Aβ 水平（Aβ（1-40）为 750.8±171.3 pg/ml）高于阿尔茨海默病患者的报道，但他们的认知状态相对正常，特别是透析时间较长的患者。
透析器可有效降低全身循环中的 Aβ 水平。反复快速降低血浆 Aβ 水平可能有助于维持认知状态。
