Chan A W, MacFarlane I A, Bowsher D
Diabetic Clinic, Walton Hospital, Liverpool, UK.
Diabetes Res. 1990 May;14(1):15-9.
Previous studies have suggested that acute hyperglycaemia may affect pain thresholds in non-diabetic subjects. We investigated the effects of acute fluctuations in blood glucose on the perception of pain in diabetic patients with and without painful diabetic neuropathy. Rapid swings in blood glucose concentration produced by IV glucose injection did not alter heat pain thresholds in diabetic patients without symptomatic neuropathy. Also, marked changes in neuropathic pain were not accompanied by significant alterations in blood glucose concentration in diabetic patients with painful neuropathy. Therefore, the alleged effects of acute hyperglycaemia on pain perception described in non-diabetic subjects are not reproduced in diabetic patients.
先前的研究表明，急性高血糖可能会影响非糖尿病患者的疼痛阈值。我们调查了血糖急性波动对患有和未患有疼痛性糖尿病神经病变的糖尿病患者疼痛感知的影响。静脉注射葡萄糖引起的血糖浓度快速波动并未改变无症状神经病变的糖尿病患者的热痛阈值。此外，有疼痛性神经病变的糖尿病患者，神经病理性疼痛的显著变化并未伴有血糖浓度的显著改变。因此，非糖尿病患者中所描述的急性高血糖对疼痛感知的所谓影响在糖尿病患者中并未重现。
