Adegbehingbe Bernice O, Oluwatoyin H Onakpoya
Ophthalmology Unit, Department of Surgery, College of Health Sciences, Obafemi Awolowo University; Ile-Ife, Osun State, Nigeria.
Middle East Afr J Ophthalmol. 2008 Apr;15(2):57-60. doi: 10.4103/0974-9233.51993.
5-Fluorouracil (5-FU) is an anti-metabolite used as an adjunct during the initial stages of a trabeculectomy to prevent excessive post-operative scarring and thus reduce the risk of failure.
To assess the effects of intra-operative 5-FU in trabeculectomy in Nigerians.
Trabeculectomy with an intra-operative sponge soaked with 5-FU was performed in 49 eyes of 34 patients. The reduction in intra-ocular pressure (IOP), Visual acuity changes and complications were noted.
The mean presenting and preoperative IOP was 35.6+/-12.5mmHg and 25.5+/-6.6mmHg respectively. The mean post-operative IOP was 10.0+/- 5.2mmHg on the second post-operative day and 16.5+/7.3mmHg at 3 months. Post-operative complications included ocular hypotony in 4 (25 percent), shallowing of anterior chamber in 3 (18.8 percent), hyphema and cystic bleb in 2 (12.5 percent) each. None had bleb failure. 5 FU appears to reduce the relative risk of failure of trabeculectomy in those undergoing surgery for the first time (relative risk 0.29, 95 percent confidence interval 0.16 to 0.53).
The use of 5-FU during trabeculectomy is associated with significant benefit in terms of intraocular pressure lowering beyond 3 months postoperatively. The results of surgery in Nigerian patients compare well with other reported series.
5-氟尿嘧啶（5-FU）是一种抗代谢药物，在小梁切除术的初始阶段用作辅助药物，以防止术后过度瘢痕形成，从而降低手术失败的风险。
评估术中使用5-FU对尼日利亚人小梁切除术的效果。
对34例患者的49只眼进行小梁切除术，术中使用浸泡有5-FU的海绵。记录眼压降低情况、视力变化及并发症。
术前平均眼压为35.6±12.5mmHg，术中平均眼压为25.5±6.6mmHg。术后第二天平均眼压为10.0±5.2mmHg，3个月时为16.5±7.3mmHg。术后并发症包括4例（25%）低眼压、3例（18.8%）前房变浅、2例（12.5%）前房积血和囊状滤过泡。无一例滤过泡失败。5-FU似乎降低了首次接受手术的患者小梁切除术失败的相对风险（相对风险0.29，95%置信区间0.16至0.53）。
小梁切除术中使用5-FU在术后3个月以上的眼压降低方面具有显著益处。尼日利亚患者的手术结果与其他报道的系列研究结果相当。
