青光眼手术中的伤口调节：一项系统评价
Wound Modulations in Glaucoma Surgery: A Systematic Review.
作者信息
Dave Bhoomi, Patel Monica, Suresh Sruthi, Ginjupalli Mahija, Surya Arvind, Albdour Mohannad, Kooner Karanjit S
机构信息
Department of Ophthalmology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
Drexel University College of Medicine, Philadelphia, PA 19129, USA.
出版信息
Bioengineering (Basel). 2024 Apr 30;11(5):446. doi: 10.3390/bioengineering11050446.
Excessive fibrosis and resultant poor control of intraocular pressure (IOP) reduce the efficacy of glaucoma surgeries. Historically, corticosteroids and anti-fibrotic agents, such as mitomycin C (MMC) and 5-fluorouracil (5-FU), have been used to mitigate post-surgical fibrosis, but these have unpredictable outcomes. Therefore, there is a need to develop novel treatments which provide increased effectiveness and specificity. This review aims to provide insight into the pathophysiology behind wound healing in glaucoma surgery, as well as the current and promising future wound healing agents that are less toxic and may provide better IOP control.
过度纤维化以及由此导致的眼内压（IOP）控制不佳会降低青光眼手术的疗效。从历史上看，皮质类固醇和抗纤维化药物，如丝裂霉素C（MMC）和5-氟尿嘧啶（5-FU），已被用于减轻术后纤维化，但这些药物的效果不可预测。因此，需要开发具有更高有效性和特异性的新型治疗方法。本综述旨在深入了解青光眼手术伤口愈合背后的病理生理学，以及目前和未来有前景的伤口愈合药物，这些药物毒性较小，可能能更好地控制眼压。
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