幕上多发性硬化病变影响瞬目反射试验。
Supratentorial multiple sclerosis lesions affect the blink reflex test.
作者信息
Mikropoulos Efthimios H, Papathanasiou Afroditi A, Hadjigeorgiou Georgios, Tsironi Evangelia, Papadimitriou Alex
机构信息
Department of Neurology, Faculty of Medicine, School of Health Sciences, University of Thessaly, P.O. Box 1400, Mezourlo Hill, Larissa, Greece.
出版信息
Open Neurol J. 2010 Sep 8;4:92-9. doi: 10.2174/1874205X01004010092.
INTRODUCTION
The Blink Reflex Test (BRT) is a neurophysiological examination used for evaluation of brainstem reflex circuits. MRI is the most precise modality for evaluation of MS lesion anatomy. Our study objective was to investigate how the functional results of the neurophysiological BRT relate to the anatomy of MS lesions in routine MRI studies.
METHODS
65 MS patients underwent the BRT within 2 months of a brain MRI showing demyelinating lesions.
RESULTS
The overall sensitivity of the BRT was 90.8%, while in patients with at least one brainstem lesion and no brainstem lesions it was 91.4% and 90%, respectively.
DISCUSSION
The presence of brainstem lesions does not significantly affect BRT sensitivity. This points to the influence of supratentorial MS lesions on the BRT. Gender, age, disease duration, type of MS, acuteness of an MS event and whether MS diagnosis was recent or not were not variables affecting the results.
引言
眨眼反射测试（BRT）是一种用于评估脑干反射回路的神经生理学检查。磁共振成像（MRI）是评估多发性硬化症（MS）病变解剖结构最精确的方式。我们的研究目的是在常规MRI研究中探究神经生理学BRT的功能结果与MS病变解剖结构之间的关系。
方法
65例MS患者在脑部MRI显示脱髓鞘病变后的2个月内接受了BRT检查。
结果
BRT的总体敏感性为90.8%，而在至少有一个脑干病变和无脑干病变的患者中，其敏感性分别为91.4%和90%。
讨论
脑干病变的存在对BRT敏感性没有显著影响。这表明幕上MS病变对BRT有影响。性别、年龄、病程、MS类型、MS事件的急性程度以及MS诊断是否为近期诊断均不是影响结果的变量。
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