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严重头部损伤的手术干预:实施救命但非恢复性手术时的伦理考虑。

Surgical intervention for severe head injury: ethical considerations when performing life-saving but non-restorative surgery.

机构信息

Department of Neurosurgery, Sir Charles Gairdner Hospital and Royal Perth Hospital, Perth, Western Australia, Australia.

出版信息

Acta Neurochir (Wien). 2011 May;153(5):1105-10. doi: 10.1007/s00701-011-0974-9. Epub 2011 Feb 24.

DOI:10.1007/s00701-011-0974-9
PMID:21347576
Abstract

BACKGROUND

The aim of this study was to compare the predicted outcome with observed outcome in those patients who have had a unilateral decompressive craniectomy following evacuation of an intracranial mass lesion and to consider some of the ethical issues that need to be addressed when performing life-saving but non-restorative surgery.

METHODS

By using the web-based outcome prediction model developed by the CRASH trial collaborators predicted and observed outcomes were compared for those patients who had had a unilateral decompression after evacuation of a mass lesion in the two major neurotrauma hospitals in Western Australia between 2004 and 2008. Three cases were selected with differing outcome predictions.

RESULTS

For the three selected cases the predicted risk of an unfavourable outcome at 6 months was 65.8%, 78.9% and 91.3%, respectively. For the 11 patients in this cohort with an outcome prediction between 61% and 70%, the observed outcome at 18 months (GOS) was: 5 had a good outcome, 4 were moderately disabled, and 3 were severely disabled. For the ten patients with an outcome prediction between 90-100%, observed outcome confirmed: one patient was moderately disabled, four patients were severely disabled, one patient was in a permanent vegetative state, and four patients had died.

CONCLUSION

As the index of injury severity (as adjudged by the CRASH outcome prediction model) increases, clinical decision making and discussion with surrogates must reflect the evidence provided by observed outcome, prior to life-saving but potentially non-restorative decompressive surgery.

摘要

背景

本研究旨在比较行颅内占位病变清除术后单侧去骨瓣减压术患者的预测结果与实际结果,并探讨在进行挽救生命但非恢复性手术时需要考虑的一些伦理问题。

方法

通过使用 CRASH 试验协作组开发的基于网络的预后预测模型,比较了 2004 年至 2008 年期间西澳大利亚州两家主要神经创伤医院行占位病变清除术后行单侧减压的患者的预测和实际结果。选择了三个具有不同预后预测的病例。

结果

对于这三个选定的病例,预测的 6 个月不良预后风险分别为 65.8%、78.9%和 91.3%。在该队列的 11 名预后预测在 61%至 70%之间的患者中,18 个月时的观察结果(GOS)为:5 人预后良好,4 人中度残疾,3 人重度残疾。对于预后预测在 90%-100%之间的 10 名患者,观察结果证实:1 人中度残疾,4 人重度残疾,1 人处于持续植物状态,4 人死亡。

结论

随着损伤严重程度指标(由 CRASH 预后预测模型判断)的增加,在进行挽救生命但可能非恢复性减压手术之前,临床决策和与代理人的讨论必须反映观察结果提供的证据。

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