Xue Xiang, Gong Li-kun, Ren Jin
State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Shanghai Institute for Biological Sciences, Chinese Academy of Sciences, Shanghai 201203, China.
Yao Xue Xue Bao. 2010 Oct;45(10):1199-204.
Drug-induced nephrotoxicity is very common in both new drug development and clinic practice. Various drugs can induce kidney injuries, including tubulointerstitial, glomerular and renal vascular disease. To investigate the mechanism of drug induced nephrotoxicity is important for risk reduction of new drug development, reasonable drug usage, early discovery and effective prevention/treatment of adverse effects in clinics.
药物性肾毒性在新药研发和临床实践中都非常常见。多种药物可导致肾损伤，包括肾小管间质、肾小球和肾血管疾病。研究药物性肾毒性的机制对于降低新药研发风险、合理用药、早期发现以及临床不良反应的有效预防/治疗都很重要。
