Gazzaruso Carmine, Coppola Adriana, Giustina Andrea
Internal Medicine, Vascular and Endocrine-Metabolic Diseases Unit and Centre for Applied Clinical Research (Ce.R.C.A.) Clinical Institute Beato Matteo ICBM, Hospital Group San Donato, Vigevano, Italy.
Curr Diabetes Rev. 2011 Mar;7(2):143-7. doi: 10.2174/157339911794940693.
The review deals with recent findings regarding the association between erectile dysfunction (ED) and coronary artery disease (CAD) in patients with diabetes. Indeed recent longitudinal studies have shown that ED is able to predict future cardiovascular events not only in nondiabetic but also in diabetic patients. In addition, in diabetic patients ED seems to be strongly associated with the presence of silent CAD. The mechanism by which ED is linked to CAD seems to be the presence of endothelial dysfunction. This pathophysiological mechanism has been extensively analysed. The possible clinical usefulness of ED to identify diabetic patients with silent CAD or at particularly high cardiovascular risk has been discussed in the review. At last, the review reports current guidelines and recent data available in the literature on the treatment of ED in patients with and without CAD and on the prevention of CAD in patients with ED.
这篇综述探讨了糖尿病患者勃起功能障碍（ED）与冠状动脉疾病（CAD）之间关联的最新研究结果。近期的纵向研究确实表明，ED不仅能够预测非糖尿病患者，还能预测糖尿病患者未来的心血管事件。此外，在糖尿病患者中，ED似乎与无症状CAD的存在密切相关。ED与CAD相关的机制似乎是内皮功能障碍的存在。这种病理生理机制已得到广泛分析。综述中讨论了ED在识别无症状CAD或心血管风险特别高的糖尿病患者方面可能的临床应用价值。最后，该综述报告了目前关于患有和未患有CAD的患者勃起功能障碍治疗以及患有ED的患者预防CAD的指南和文献中的最新数据。
