Maes M, Bosmans E, Suy E, Vandervorst C, De Jonckheere C, Raus J
Psychiatric Center, St.-Jozef, Munsterbilzen, Belgium.
Neuropsychobiology. 1990;24(3):115-20. doi: 10.1159/000119472.
We determined the following immune parameters in drug-free, major depressed patients and in age- and sex-matched healthy controls: the number and percentage of interleukin-2 receptor (IL-2R) bearing cells (CD25+, anti-TAC), serum circulating levels of soluble (s)IL-2Rs, the pre- and postdexamethasone phytohemagglutinin (PHA)-induced accumulation of sIL-2Rs in culture supernatant, and the number of T helper (CD4+) and T suppressor (CD8+) cells. In comparison with normal volunteers, patients with major depression had a higher number and percentage of CD25+ cells, higher concentrations of serum circulating sIL-2Rs, higher supernatant sIL-2Rs after stimulation with PHA, and a higher number of CD4+ cells. The CD4+/CD8+ ratio and the number of CD4+ cells were significantly and positively related to the number of cells expressing the CD25+ antigen. These results may indicate that depressed patients display an increased number of T cells in an early phase of activation.
携带白细胞介素-2受体（IL-2R）的细胞数量及百分比（CD25+，抗TAC）、可溶性（s）IL-2R的血清循环水平、地塞米松前后植物血凝素（PHA）诱导培养上清液中sIL-2R的积累情况，以及辅助性T细胞（CD4+）和抑制性T细胞（CD8+）的数量。与正常志愿者相比，重度抑郁症患者的CD25+细胞数量及百分比更高、血清循环sIL-2R浓度更高、PHA刺激后上清液中的sIL-2R更高，且CD4+细胞数量更多。CD4+/CD8+比值和CD4+细胞数量与表达CD25+抗原的细胞数量显著正相关。这些结果可能表明，抑郁症患者在激活早期阶段的T细胞数量增加。
