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[持续气道正压通气(CPAP)治疗对哮喘合并阻塞性睡眠呼吸暂停综合征患者慢性夜间咳嗽的抑制作用]

[Suppression of chronic nocturnal cough during continuous positive airway pressure (CPAP) treatment in a patient with asthma and obstructive sleep apnea syndrome].

作者信息

Brzecka Anna, Pawelec-Winiarz Magdalena, Piesiak Paweł, Nowak Elżbieta, Jankowska Renata

机构信息

Katedra i Klinika Pulmonologii i Nowotworów Płuc, Akademia Medyczna we Wrocławiu, ul. Grabiszyńska 105, 53–439 Wrocław.

出版信息

Pneumonol Alergol Pol. 2011;79(2):121-6.

Abstract

Sleep disruption is a common feature both in the patients with chronic cough and in the patients with obstructive sleep apnea syndrome (OSAS). There is increasing body of evidence that chronic nocturnal cough may be related to OSAS. We describe a 59 years old, obese man (BMI 38,6 kg/m(2)) with asthma and chronic nocturnal cough not responding to the optimal anti-asthmatic treatment. On the basis of nocturnal polysomnography moderate form of the OSAS has been diagnosed and the treatment with continuous positive airway pressure (CPAP) has been started. All the nocturnal symptoms, including cough, disappeared. The effect of CPAP in preventing nocturnal cough persisted at the follow-up visit after a year since diagnosis. This case indicates that nocturnal cough may be an important symptom of the OSAS and CPAP treatment - by abolishing sleep apneas and hypopneas - may also prevent chronic cough during sleep.

摘要

睡眠中断是慢性咳嗽患者和阻塞性睡眠呼吸暂停综合征(OSAS)患者的共同特征。越来越多的证据表明,慢性夜间咳嗽可能与OSAS有关。我们描述了一名59岁的肥胖男性(BMI 38.6 kg/m²),患有哮喘和慢性夜间咳嗽,对最佳抗哮喘治疗无反应。基于夜间多导睡眠图诊断为中度OSAS,并开始持续气道正压通气(CPAP)治疗。所有夜间症状,包括咳嗽,均消失。自诊断后一年的随访中,CPAP预防夜间咳嗽的效果持续存在。该病例表明,夜间咳嗽可能是OSAS的重要症状,CPAP治疗——通过消除睡眠呼吸暂停和呼吸浅慢——也可能预防睡眠期间的慢性咳嗽。

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