Lafond C, Sériès F, Lemière C
Sacre-Coeur Hospital, University of Montreal, Montreal, Quebec City, QC, Canada.
Eur Respir J. 2007 Feb;29(2):307-11. doi: 10.1183/09031936.00059706. Epub 2006 Oct 18.
The impact of continuous positive airway pressure (CPAP) treatment on the airway responsiveness of asthmatic subjects with obstructive sleep apnoea (OSA) has scarcely been studied. A prospective study was performed comparing the changes in airway responsiveness and quality of life in stable asthmatic OSA patients, before and 6 weeks after their nocturnal CPAP treatment. A total of 20 subjects (11 males and nine females) participated in the study. With the nocturnal CPAP treatment, the apnoea/hypopnoea index dropped from 48.1 +/- 23.6 x h(-1) to 2.6 +/- 2.5 x h(-1). There were no significant changes in airway responsiveness after CPAP treatment (provocative concentration causing a 20% fall in forced expiratory volume in one second (FEV(1); PC(20) 2.5 mg x mL(-1) (1.4-4.5)) compared with baseline (PC(20) 2.2 mg x mL(-1) (1.3-3.5)). There was no significant change in FEV(1) either. However, the asthma quality of life of the subjects improved from 5.0 +/- 1.2 at baseline to 5.8 +/- 0.9 at the end of the study. In conclusion, nocturnal continuous positive airway pressure treatment did not alter airway responsiveness or forced expiratory volume in one second in subjects with stable mild-to-moderate asthma and newly diagnosed obstructive sleep apnoea. However, nocturnal continuous positive airway pressure treatment did improve asthma quality of life.
持续气道正压通气（CPAP）治疗对患有阻塞性睡眠呼吸暂停（OSA）的哮喘患者气道反应性的影响鲜有研究。本研究进行了一项前瞻性研究，比较稳定期哮喘合并OSA患者在夜间CPAP治疗前和治疗6周后气道反应性和生活质量的变化。共有20名受试者（11名男性和9名女性）参与了该研究。通过夜间CPAP治疗，呼吸暂停/低通气指数从48.1±23.6次/小时降至2.6±2.5次/小时。CPAP治疗后气道反应性无显著变化（引起一秒用力呼气量（FEV₁）下降20%的激发浓度（PC₂₀）为2.5mg/mL（1.4 - 4.5）），与基线水平（PC₂₀为2.2mg/mL（1.3 - 3.5））相比。FEV₁也无显著变化。然而，受试者的哮喘生活质量从基线时的5.0±1.2提高到研究结束时的5.8±0.9。总之，夜间持续气道正压通气治疗并未改变稳定期轻度至中度哮喘且新诊断为阻塞性睡眠呼吸暂停患者的气道反应性或一秒用力呼气量。然而，夜间持续气道正压通气治疗确实改善了哮喘患者的生活质量。
