Department of Public Health, University of Szeged Faculty of Medicine, H-6720, Szeged, Dóm tér 10., Hungary.
J Appl Toxicol. 2011 Jul;31(5):471-6. doi: 10.1002/jat.1664. Epub 2011 Feb 23.
Cadmium, a toxic heavy metal with various applications in technology, can affect people both by environmental (foodborne) and occupational (inhalation) exposure and can cause nervous system damage. To model this, rats were subacutely treated either with CdCl(2) solution per os (3.0 mg kg(-1) b.w.) or nanoparticulate CdO(2) (particle size ca 65 nm) by intratracheal instillation (0.04 mg kg(-1) b.w.) alone or in sequential combination. Nervous system effects were observed at different levels of function (open field behavior, cortical electrical activity, nerve action potential) and some general toxicological indicators were also measured. Three weeks of oral plus one week of intratracheal exposure caused significant reduction of body weight gain and open field motility. Lengthening of latency of sensory evoked potentials, observed in all treated rats, was also the most significant in the group receiving oral plus intratracheal treatment. Conduction velocity of the tail nerve was likewise decreased in all treated groups. Several of the effects pointed to a potentiating interaction between the two forms of Cd. Modeling environmental and occupational Cd exposure by oral and intratracheal application in rats was feasible, with results suggesting serious negative health effects in humans suffering such a combined exposure.
镉是一种有毒重金属，在技术上有多种应用，可以通过环境（食源性）和职业（吸入）暴露对人体造成影响，并可能导致神经系统损伤。为了模拟这种情况，大鼠经口给予 CdCl2 溶液（3.0mgkg-1bw）或经气管内滴注纳米级 CdO2（粒径约 65nm，0.04mgkg-1bw）进行亚急性处理，单独或连续组合处理。在不同的功能水平（旷场行为、皮质电活动、神经动作电位）观察神经系统效应，并测量了一些一般的毒理学指标。口服加气管内暴露 3 周和 1 周导致体重增加和旷场运动显著减少。所有接受治疗的大鼠的感觉诱发电位潜伏期延长，在接受口服加气管内治疗的大鼠中最为显著。尾部神经的传导速度在所有治疗组中均降低。这些影响中的一些表明两种形式的 Cd 之间存在增强相互作用。通过在大鼠中经口和气管内应用来模拟环境和职业性 Cd 暴露是可行的，结果表明，遭受这种联合暴露的人类健康受到严重的负面影响。
