Dogra Shashi, Waseem Mohd, Khanna Ashok Kumar, Kaw Jawahir Lal
Industrial Toxicology Research Centre, Post Box, No. 80, M.G. Marg, Lucknow 226001, India. itrc@sanchar net.com
Indian J Exp Biol. 2002 Mar;40(3):262-7.
Rats were intratracheally (i.t.) exposed to 36.5 or 27.5 microg of cadmium (Cd) as soluble cadmium chloride (CdCl2) and insoluble cadmium oxide (CdO) salts. The retention of metal in lungs, liver and kidney was assessed by atomic adsorption spectrophotometer. The animals were intraperitoneally (i.p.) primed with sheep red blood cells (SRBC) and assessed for the number of antibody forming cells in lung associated lymph nodes (LALN) and spleen. Both the compounds had similar retention of metal in lungs but CdO induced more pulmonary inflammatory and degradative changes than CdCl2. The larger influx of polymorphonuclear cells (PMNs) following CdO exposure appears to be due to the absence of protection afforded by Cd induced metallothionein cytoplasmic protein while the Cd metallothionein complex formed in the case of CdCl2 is more protective. However both forms of Cd had similar local immunosuppressive potential but CdO had more prolonged suppressive effect.
将大鼠经气管内（i.t.）暴露于36.5或27.5微克的镉（Cd），分别以可溶性氯化镉（CdCl2）和不溶性氧化镉（CdO）盐的形式。通过原子吸收分光光度计评估金属在肺、肝和肾中的潴留情况。给动物腹腔内（i.p.）注射绵羊红细胞（SRBC）进行致敏，并评估肺相关淋巴结（LALN）和脾脏中抗体形成细胞的数量。两种化合物在肺中对金属的潴留情况相似，但CdO比CdCl2诱导了更多的肺部炎症和降解性变化。CdO暴露后多形核细胞（PMN）的大量涌入似乎是由于Cd诱导的金属硫蛋白细胞质蛋白未提供保护，而在CdCl2情况下形成的Cd金属硫蛋白复合物更具保护作用。然而，两种形式的Cd具有相似的局部免疫抑制潜力，但CdO具有更持久的抑制作用。
