Center for Membrane Pumps in Cells and Disease--PUMPKIN, Danish National Research Foundation, University of Copenhagen, Frederiksberg C, Denmark.
Annu Rev Biophys. 2011;40:243-66. doi: 10.1146/annurev.biophys.093008.131331.
P-type ATPases form a large superfamily of cation and lipid pumps. They are remarkably simple with only a single catalytic subunit and carry out large domain motions during transport. The atomic structure of P-type ATPases in different conformations, together with ample mutagenesis evidence, has provided detailed insights into the pumping mechanism by these biological nanomachines. Phylogenetically, P-type ATPases are divided into five subfamilies, P1-P5. These subfamilies differ with respect to transported ligands and the way they are regulated.
P 型 ATP 酶构成了一个庞大的阳离子和脂质泵超级家族。它们非常简单，只有一个单一的催化亚基，并在运输过程中进行大的结构域运动。不同构象的 P 型 ATP 酶的原子结构，以及大量的突变证据，为这些生物纳米机器的泵送机制提供了详细的见解。从系统发生学上讲，P 型 ATP 酶分为 P1-P5 五个亚家族。这些亚家族在转运配体和调节方式上存在差异。
