Prevention and Early Intervention Program for Psychoses (PEPP), London Health Sciences Center, and Department of Psychiatry, University of Western Ontario, London, Ontario, Canada.
Early Interv Psychiatry. 2009 Feb;3(1):75-9. doi: 10.1111/j.1751-7893.2008.00100.x.
To determine the incidence of concurrent substance misuse among individuals entering first-episode psychosis treatment, and examine whether patients with concurrent substance misuse differ on variables relevant to service planning.
Consecutive patients (n=376) were assessed using standardized instruments.
Twenty-two per cent met abuse or dependence criteria for a single substance, and 8% met criteria for two substances. Most met criteria for marijuana or marijuana and alcohol. The majority of patients with a concurrent disorder were male, and on average they were 3.5 years younger at psychosis onset. Patients with a concurrent disorder experienced worse 'positive' and anxiety symptoms in the month before treatment. Premorbidly they had better social functioning, but worse academic functioning.
There are important differences between patients entering first-episode psychosis treatment with and without a concurrent substance misuse. Early intervention efforts might be informed by our accumulating knowledge about the characteristics of patients who have both disorders.
确定首次出现精神病症状接受治疗的个体中同时存在物质滥用的发生率，并探讨同时存在物质滥用的患者在与服务计划相关的变量上是否存在差异。
对连续就诊的患者（n=376）使用标准化工具进行评估。
22%的患者符合单一物质滥用或依赖的标准，8%的患者符合两种物质的标准。大多数患者同时存在大麻或大麻和酒精滥用的情况。大多数同时存在精神障碍的患者为男性，他们在精神病发病时平均年轻 3.5 岁。同时存在精神障碍的患者在治疗前一个月的“阳性”和焦虑症状更严重。发病前他们的社会功能较好，但学业功能较差。
首次出现精神病症状接受治疗的患者中，同时存在物质滥用的患者与不存在物质滥用的患者存在重要差异。我们对同时存在两种障碍的患者的特征的了解，可能会为早期干预措施提供依据。
