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Inhibition of granulocyte migration by tiotropium bromide.
Respir Res. 2011 Feb 27;12(1):24. doi: 10.1186/1465-9921-12-24.
2
Tiotropium suppresses acetylcholine-induced release of chemotactic mediators in vitro.
Respir Med. 2007 Nov;101(11):2386-94. doi: 10.1016/j.rmed.2007.06.009. Epub 2007 Aug 29.
4
β₂ long-acting and anticholinergic drugs control TGF-β1-mediated neutrophilic inflammation in COPD.
Biochim Biophys Acta. 2012 Jul;1822(7):1079-89. doi: 10.1016/j.bbadis.2012.03.002. Epub 2012 Mar 13.
5
Acetylcholine-induced proliferation of fibroblasts and myofibroblasts in vitro is inhibited by tiotropium bromide.
Life Sci. 2007 May 30;80(24-25):2270-3. doi: 10.1016/j.lfs.2007.02.034. Epub 2007 Mar 2.
6
[Tiotropium as a controller of bronchoconstriction].
Pol Merkur Lekarski. 2004 May;16 Suppl 1:75-6, 78.
7
Acetylcholine mediates the release of IL-8 in human bronchial epithelial cells by a NFkB/ERK-dependent mechanism.
Eur J Pharmacol. 2008 Mar 17;582(1-3):145-53. doi: 10.1016/j.ejphar.2007.12.029. Epub 2008 Jan 9.
8
Tiotropium bromide exerts anti-inflammatory activity in a cigarette smoke mouse model of COPD.
Pulm Pharmacol Ther. 2010 Aug;23(4):345-54. doi: 10.1016/j.pupt.2010.03.008. Epub 2010 Apr 1.
9
Increased levels of Th17 cells are associated with non-neuronal acetylcholine in COPD patients.
Immunobiology. 2014 May;219(5):392-401. doi: 10.1016/j.imbio.2014.01.004. Epub 2014 Jan 25.
10
Suppression of IL-8 production from airway cells by tiotropium bromide in vitro.
Int J Chron Obstruct Pulmon Dis. 2011;6:439-48. doi: 10.2147/COPD.S23695. Epub 2011 Sep 6.

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Muscarinic receptor antagonists and airway inflammation: A systematic review on pharmacological models.
Heliyon. 2022 Jun 22;8(6):e09760. doi: 10.1016/j.heliyon.2022.e09760. eCollection 2022 Jun.
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Cholinergic System and Its Therapeutic Importance in Inflammation and Autoimmunity.
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The Impact of Muscarinic Receptor Antagonists on Airway Inflammation: A Systematic Review.
Int J Chron Obstruct Pulmon Dis. 2021 Feb 12;16:257-279. doi: 10.2147/COPD.S285867. eCollection 2021.
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Airway Innervation and Plasticity in Asthma.
Physiology (Bethesda). 2019 Jul 1;34(4):283-298. doi: 10.1152/physiol.00050.2018.
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Long-term safety of bilateral targeted lung denervation in patients with COPD.
Int J Chron Obstruct Pulmon Dis. 2018 Jul 16;13:2163-2172. doi: 10.2147/COPD.S158748. eCollection 2018.
10
Comedications alter drug-induced liver injury reporting frequency: Data mining in the WHO VigiBase™.
Regul Toxicol Pharmacol. 2015 Aug;72(3):481-90. doi: 10.1016/j.yrtph.2015.05.004. Epub 2015 May 16.

本文引用的文献

1
Tiotropium bromide exerts anti-inflammatory activity in a cigarette smoke mouse model of COPD.
Pulm Pharmacol Ther. 2010 Aug;23(4):345-54. doi: 10.1016/j.pupt.2010.03.008. Epub 2010 Apr 1.
2
Anti-inflammatory effects of salmeterol/fluticasone, tiotropium/fluticasone or tiotropium in COPD.
Eur Respir J. 2009 Apr;33(4):778-84. doi: 10.1183/09031936.00115308. Epub 2009 Jan 7.
3
A 4-year trial of tiotropium in chronic obstructive pulmonary disease.
N Engl J Med. 2008 Oct 9;359(15):1543-54. doi: 10.1056/NEJMoa0805800. Epub 2008 Oct 5.
4
Neutral red uptake assay for the estimation of cell viability/cytotoxicity.
Nat Protoc. 2008;3(7):1125-31. doi: 10.1038/nprot.2008.75.
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Long-term effects of budesonide on inflammatory status in COPD.
COPD. 2008 Apr;5(2):97-104. doi: 10.1080/15412550801941000.
6
Pulmonary fibroblasts, an emerging target for anti-obstructive drugs.
Naunyn Schmiedebergs Arch Pharmacol. 2008 Aug;378(2):193-201. doi: 10.1007/s00210-008-0264-0. Epub 2008 Feb 13.
7
Acetylcholine mediates the release of IL-8 in human bronchial epithelial cells by a NFkB/ERK-dependent mechanism.
Eur J Pharmacol. 2008 Mar 17;582(1-3):145-53. doi: 10.1016/j.ejphar.2007.12.029. Epub 2008 Jan 9.
8
Increased systemic inflammation is a risk factor for COPD exacerbations.
Chest. 2008 Feb;133(2):350-7. doi: 10.1378/chest.07-1342. Epub 2008 Jan 15.
9
Tiotropium suppresses acetylcholine-induced release of chemotactic mediators in vitro.
Respir Med. 2007 Nov;101(11):2386-94. doi: 10.1016/j.rmed.2007.06.009. Epub 2007 Aug 29.
10
The non-neuronal cholinergic system in the airways: an unappreciated regulatory role in pulmonary inflammation?
Pharmacol Ther. 2007 Aug;115(2):208-22. doi: 10.1016/j.pharmthera.2007.05.007. Epub 2007 May 25.

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