Magee Laura A, von Dadelszen Peter, Allen Victoria M, Ansermino John M, Audibert François, Barrett Jon, Brant Rollin, Bujold Emmanuel, Crane Joan M G, Demianczuk Nestor, Joseph K S, Lee Shoo K, Piedboeuf Bruno, Smith Graeme, Synnes Anne, Walker Mark, Whittle Wendy, Wood Stephen, Lee Tang, Li Jing, Payne Beth, Liston Robert M
Department of Medicine, University of British Columbia, Vancouver BC; Department of Obstetrics and Gynaecology, University of British Columbia, Vancouver BC; School of Population and Public Health, University of British Columbia, Vancouver BC; Child and Family Research Institute, University of British Columbia, Vancouver BC.
Department of Obstetrics and Gynaecology, University of British Columbia, Vancouver BC; School of Population and Public Health, University of British Columbia, Vancouver BC; Child and Family Research Institute, University of British Columbia, Vancouver BC.
J Obstet Gynaecol Can. 2011 Feb;33(2):111-120. doi: 10.1016/S1701-2163(16)34795-8.
The Canadian Perinatal Network (CPN) maintains an ongoing national database focused on threatened very preterm birth. The objective of the network is to facilitate between-hospital comparisons and other research that will lead to reductions in the burden of illness associated with very preterm birth.
Women were included in the database if they were admitted to a participating tertiary perinatal unit at 22+0 to 28+6 weeks' gestation with one or more conditions most commonly responsible for very preterm birth, including spontaneous preterm labour with contractions, incompetent cervix, prolapsing membranes, preterm prelabour rupture of membranes, gestational hypertension, intrauterine growth restriction, or antepartum hemorrhage. Data were collected by review of maternal and infant charts, entered directly into standardized electronic data forms and uploaded to the CPN via a secure network.
Between 2005 and 2009, the CPN enrolled 2524 women from 14 hospitals including those with preterm labour and contractions (27.4%), short cervix without contractions (16.3%), prolapsing membranes (9.4%), antepartum hemorrhage (26.1%), and preterm prelabour rupture of membranes (23.0%). The mean gestational age at enrolment was 25.9 ± 1.9 weeks and the mean gestation age at delivery was 29.9 ± 5.1 weeks; 57.0% delivered at < 29 weeks and 75.4% at < 34 weeks. Complication rates were high and included serious maternal complications (26.7%), stillbirth (8.2%), neonatal death (16.3%), neonatal intensive care unit admission (60.7%), and serious neonatal morbidity (35.0%).
This national dataset contains detailed information about women at risk of very preterm birth. It is available to clinicians and researchers who are working with one or more CPN collaborators and who are interested in studies relating processes of care to maternal or perinatal outcomes.
加拿大围产期网络（CPN）维护着一个持续更新的全国性数据库，重点关注有早产风险的极早产情况。该网络的目标是促进医院间的比较以及其他研究，以减轻与极早产相关的疾病负担。
如果孕妇在妊娠22 + 0至28 + 6周时因一种或多种最常见的极早产原因入住参与研究的三级围产期单位，包括伴有宫缩的自发性早产、宫颈机能不全、胎膜脱垂、临产前胎膜早破、妊娠期高血压、胎儿生长受限或产前出血，则将其纳入数据库。通过查阅母婴病历收集数据，直接录入标准化电子数据表格，并通过安全网络上传至CPN。
2005年至2009年期间，CPN从14家医院招募了2524名妇女，其中包括伴有宫缩的早产（27.4%）、无宫缩的宫颈缩短（16.3%）、胎膜脱垂（9.4%）、产前出血（26.1%）和临产前胎膜早破（23.0%）。入组时的平均孕周为25.9±1.9周，分娩时的平均孕周为29.9±5.1周；57.0%的孕妇在<29周时分娩，75.4%在<34周时分娩。并发症发生率较高，包括严重的母体并发症（26.7%）、死产（8.2%）、新生儿死亡（16.3%）、新生儿重症监护病房入住（60.7%）和严重的新生儿发病率（35.0%）。
这个全国性数据集包含了有关极早产风险妇女的详细信息。临床医生和研究人员若与CPN的一个或多个合作方合作，并对研究护理过程与母体或围产期结局之间的关系感兴趣，均可使用该数据集。
