猪圆环病毒 1 型（PCV1）缺失和猪育肥场猪圆环病毒 2 暴露和感染的高流行率。

Absence of porcine circovirus type 1 (PCV1) and high prevalence of PCV 2 exposure and infection in swine finisher herds.

机构信息

Department of Veterinary & Biomedical Sciences, University of Minnesota, 1971 Commonwealth Avenue, St. Paul, MN 55108, USA.

出版信息

Virus Res. 2011 Apr;157(1):92-8. doi: 10.1016/j.virusres.2011.02.012. Epub 2011 Feb 23.

DOI:10.1016/j.virusres.2011.02.012

PMID:21352865

Abstract

Porcine circovirus (PCV) appeared in 1974 as an unidentified, innocuous viral inhabitant of cell cultures and pigs. Today PCV1 is a contaminant of some human vaccines, and PCV2 is a major pathogen of swine. PCV1 is reportedly ubiquitous in swine but nonpathogenic. Since the interplay of PCV1 and PCV2 in swine might explain variable disease results and shed light on the potential for human exposure, we analyzed in depth the prevalence of PCV1 and PCV2 infection and exposure in the U.S. finishing swine herd. Over 82% of sera from 185 farms were positive for PCV2 by PCR, whereas only 2.4% were positive for PCV1. More than 80% of PCV2 DNA-positive swine were also positive for anti-PCV2 antibodies. PCV1 was only rarely present. Exposure of swine, and therefore humans via pigs, to PCV1 is negligible. We conclude that PCV2 causes a persistent infection in pigs and that PCV1 is absent or rare in swine.

摘要

猪圆环病毒（PCV）于 1974 年首次出现，当时它是一种在细胞培养物和猪中存在的、未被识别的无害病毒。如今，PCV1 是一些人类疫苗的污染物，而 PCV2 则是猪的主要病原体。据报道，PCV1 在猪中普遍存在，但无致病性。由于 PCV1 和 PCV2 在猪中的相互作用可能解释了不同疾病结果，并揭示了人类接触的潜在可能性，因此我们深入分析了美国育肥猪群中 PCV1 和 PCV2 感染和暴露的流行情况。185 个农场的 82%以上的血清通过 PCR 检测为 PCV2 阳性，而仅 2.4%的血清为 PCV1 阳性。超过 80%的 PCV2 DNA 阳性猪也对抗 PCV2 抗体呈阳性。PCV1 则很少出现。猪的 PCV1 暴露，以及因此通过猪的人类暴露，可以忽略不计。我们的结论是，PCV2 会导致猪的持续性感染，而 PCV1 在猪中不存在或很少见。