因巴氯芬和替扎尼定撤药引起的谵妄、运动障碍和自主神经功能障碍 1 例：文献复习。
A case of delirium, motor disturbances, and autonomic dysfunction due to baclofen and tizanidine withdrawal: a review of the literature.
机构信息
Duke University Medical Center, Durham, NC 27705, USA.
出版信息
Gen Hosp Psychiatry. 2011 Jan-Feb;33(1):84.e1-2. doi: 10.1016/j.genhosppsych.2010.10.003. Epub 2010 Nov 13.
We report a case of delirium accompanied by extrapyramidal symptoms and autonomic dysfunction in a 59-year-old man following abrupt cessation of baclofen and tizanidine. An extensive search for the etiology was undertaken, but it was only after a careful history was taken that suspicion for baclofen and tizanidine withdrawal was raised. The delirium and motor disturbances resolved within 24 h of reintroduction of baclofen. Withdrawal from muscle relaxants requires a high index of suspicion but should be considered in patients who manifest signs and symptoms of withdrawal from the medications, particularly visual hallucinations, rigidity and autonomic dysfunction.
我们报告了一例 59 岁男性患者在突然停用巴氯芬和替扎尼定后出现意识障碍伴锥体外系症状和自主神经功能障碍。我们进行了广泛的病因搜索，但只有在仔细询问病史后，才怀疑是巴氯芬和替扎尼定戒断。重新使用巴氯芬后 24 小时内，意识障碍和运动障碍得到缓解。肌肉松弛剂戒断需要高度怀疑，但应考虑在出现戒断症状和体征的患者，特别是出现幻觉、僵硬和自主神经功能障碍的患者。
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