Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA.
Metabolism. 2011 Aug;60(8):1178-85. doi: 10.1016/j.metabol.2010.12.014. Epub 2011 Feb 25.
Aging is associated with declining serum levels of androgenic hormones and with increased skeletal muscle fat infiltration, an emerging risk factor for type 2 diabetes mellitus (T2DM). Androgens regulate fat mass and glucose homeostasis, but the effect of androgenic hormones on skeletal muscle fat infiltration is largely unknown. Thus, the aim of the current study was to examine the association of serum androgens and their precursors and metabolites with skeletal muscle fat infiltration and T2DM in a black male population group at high risk of T2DM. Serum androgens, estrogens, and androgen precursors and metabolites were measured using mass spectrometry; and calf skeletal muscle fat distribution (subcutaneous and intermuscular fat; skeletal muscle density) was measured using quantitative computed tomography in 472 Afro-Caribbean men 65 years and older. Bioactive androgens, testosterone, free testosterone, and dihydrotestosterone were associated with less skeletal muscle fat infiltration (r = -0.14 to -0.18, P < .05) and increased skeletal muscle density (r = 0.10 to 0.14, P < .05), independent of total adiposity. In addition, glucuronidated androgen metabolites were associated with less subcutaneous fat (r = -0.11 to -0.15, P < .05). Multivariate logistic regression analysis identified an increased level of 3α-diol-3 glucuronide (odds ratio = 1.38, P < .01) and a decreased level of dihydrotestosterone (odds ratio = 0.66, P < .01) to be significantly associated with T2DM. Our findings suggest that, in elderly black men, independent of total adiposity, bioactive androgens and glucuronidated androgen metabolites may play previously unrecognized role in skeletal muscle fat distribution. Longitudinal studies are needed to further evaluate the relationship between androgens and androgen metabolites with changes in skeletal muscle fat distribution with aging and the incidence of T2DM.
衰老是与雄激素激素水平下降和骨骼肌脂肪浸润增加相关的，后者是 2 型糖尿病（T2DM）的一个新出现的危险因素。雄激素调节脂肪量和葡萄糖内稳态，但雄激素对骨骼肌脂肪浸润的影响在很大程度上尚不清楚。因此，本研究的目的是在一个黑人男性群体中检查血清雄激素及其前体和代谢物与骨骼肌脂肪浸润和 T2DM 的关系，该群体患 T2DM 的风险较高。使用质谱法测量血清雄激素、雌激素和雄激素前体和代谢物；使用定量计算机断层扫描测量 472 名 65 岁及以上的非洲裔加勒比男性的小腿骨骼肌脂肪分布（皮下和肌间脂肪；骨骼肌密度）。生物活性雄激素、睾酮、游离睾酮和二氢睾酮与较少的骨骼肌脂肪浸润（r = -0.14 至 -0.18，P <.05）和增加的骨骼肌密度（r = 0.10 至 0.14，P <.05）相关，与总肥胖无关。此外，葡萄糖醛酸雄激素代谢物与皮下脂肪减少有关（r = -0.11 至 -0.15，P <.05）。多元逻辑回归分析确定，3α-二醇-3 葡萄糖醛酸（优势比= 1.38，P <.01）和二氢睾酮水平降低（优势比= 0.66，P <.01）与 T2DM 显著相关。我们的研究结果表明，在老年黑人男性中，独立于总肥胖，生物活性雄激素和葡萄糖醛酸雄激素代谢物可能在骨骼肌脂肪分布中发挥以前未被认识到的作用。需要进行纵向研究，以进一步评估雄激素和雄激素代谢物与衰老过程中骨骼肌脂肪分布变化以及 T2DM 发生率之间的关系。
