Servicio de Neurología, Hospital Infanta Elena, Valdemoro, Madrid, España.
Neurologia. 2011 Jun;26(5):285-90. doi: 10.1016/j.nrl.2010.10.012. Epub 2011 Feb 24.
The Lennox-Gastaut syndrome (LGS) is one of the most severe epileptic encephalopathies of childhood, characterized by electro-clinical triad of generalized spike-wave activity, slow (POL) in the electroencephalogram (EEG), multiple types of seizures and development delay. This paper intends to describe the syndrome in a patient with a history of hypoxic-ischaemic encephalopathy and Lennox-Gastaut syndrome, and a good response to treatment with levetiracetam (LEV).
Descriptive study on the development of a 3 year old child with intrauterine asphyxia, multiorgan failure, metabolic acidosis, hypovolemic shock, and seizures with cerebral oedema, who developed a West syndrome, resistant to drug treatment. The semiology of seizures progressively changed to generalized episodes of hypertonia and myoclonus, with slow spike-wave electroencephalographic activity.
With the diagnosis of Lennox-Gastaut syndrome the patient was treated with levetiracetam, showing a substantial improvement in the cognitive sphere, in the control of seizures, and electroencephalographic findings.
Lennox-Gastaut syndrome is one of the most severe epileptic syndromes in paediatric patients. Levetiracetam can help cognitive improvement, and contribute to seizure control in these patients.
Lennox-Gastaut 综合征（LGS）是儿童时期最严重的癫痫性脑病之一，其特征为全身性棘慢波活动、脑电图（EEG）中的慢波（POL）、多种类型的癫痫发作和发育迟缓的电临床三联征。本文旨在描述一名患有缺氧缺血性脑病和 Lennox-Gastaut 综合征病史的患者的综合征，以及对左乙拉西坦（LEV）治疗反应良好的情况。
对一名 3 岁儿童的发育情况进行描述性研究，该儿童宫内窒息，多器官衰竭，代谢性酸中毒，低血容量性休克，伴有脑水肿的癫痫发作，发展为 West 综合征，对药物治疗有耐药性。癫痫发作的症状逐渐转变为全身性张力过高和肌阵挛发作，伴有慢棘慢波的脑电图活动。
诊断为 Lennox-Gastaut 综合征后，该患者接受了左乙拉西坦治疗，在认知领域、癫痫发作控制和脑电图发现方面均有显著改善。
Lennox-Gastaut 综合征是儿童中最严重的癫痫综合征之一。左乙拉西坦可以帮助改善认知，并有助于控制这些患者的癫痫发作。
