瘦素给药对宫内发育受限大鼠模型生长和骨骼发育的影响：初步研究。
Leptin administration affects growth and skeletal development in a rat intrauterine growth restriction model: preliminary study.
机构信息
School of Nutritional Sciences, The Robert H. Smith Faculty of Agriculture, Food and Environment, The Hebrew University of Jerusalem, Rehovot, Israel.
出版信息
Nutrition. 2011 Sep;27(9):973-7. doi: 10.1016/j.nut.2010.10.020. Epub 2011 Feb 25.
OBJECTIVE
Skeletal abnormalities are one of the hallmarks of growth delay during gestation. The aim of this study was to determine changes induced by leptin in skeletal growth and development in a rat model of intrauterine growth retardation (IUGR) and to elucidate the possible underlying mechanisms.
METHODS
Intrauterine growth retardation was induced prepartum and the effects of leptin to mothers prenatally or to offspring postnatally were studied. Radii were harvested and tested mechanically and structurally. Tibias were evaluated for growth-plate morphometry.
RESULTS
On day 40 postpartum, total bone length and mineral density and tibial growth-plate width and numbers of cells within its zones of offspring treated with leptin were significantly greater than in the control group.
CONCLUSION
Postnatal leptin administration in an IUGR model improves the structural properties and elongation rate of bone. These findings could pave the way to preventing some phenotypic presentations of IUGR.
目的
骨骼异常是胎儿发育迟缓的特征之一。本研究旨在确定瘦素在宫内发育迟缓（IUGR）大鼠模型中对骨骼生长和发育的影响，并阐明可能的潜在机制。
方法
产前诱导宫内发育迟缓，研究瘦素对母亲产前或后代产后的影响。采集桡骨进行力学和结构测试。评估胫骨生长板的形态计量学。
结果
产后 40 天，接受瘦素治疗的后代的总骨长度和骨密度以及胫骨生长板宽度和其各区域细胞数量均显著大于对照组。
结论
IUGR 模型中产后给予瘦素可改善骨骼的结构特性和伸长率。这些发现可能为预防 IUGR 的一些表型表现铺平道路。
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