Chemical Engineering Department, National Research Center, Dokki, Giza, Egypt.
Biosens Bioelectron. 2011 Apr 15;26(8):3542-8. doi: 10.1016/j.bios.2011.01.042. Epub 2011 Feb 24.
A novel and stable non-enzymatic glucose sensor was developed based on the chemical reduction of Cu(2)O nanoparticles on Carbon Vulcan XC-72 using NaBH(4) as the reducing agent via the impregnation method. Different molar ratios of NaBH(4) to the copper salt were employed during the reduction step. This was found to affect the morphology; composition and structure of the prepared samples as investigated by TEM, EDX and XRD analyses. Cyclic voltammetry and chronoamperometry were applied to examine the electrocatalytic activity of the different samples of Cu(2)O/Carbon Vulcan XC-72 towards glucose oxidation in alkaline medium. The 'x70' sample got the highest oxidation current density and the lowest oxidation potential. The performance of this sensor was evaluated showing a wide linear range up to 6mM with sensitivity of 629 μA cm(-2)mM(-1) and detection limit of 2.4 μM. Its good tolerance to ascorbic acid with long-term stability elects Cu(2)O/Carbon Vulcan XC-72 as a promising glucose sensor.
一种新型稳定的非酶葡萄糖传感器是基于化学还原法在碳 Vulcan XC-72 上制备的 Cu(2)O 纳米粒子，使用 NaBH(4)作为还原剂。在还原步骤中使用不同摩尔比的 NaBH(4)与铜盐。通过 TEM、EDX 和 XRD 分析发现，这会影响所制备样品的形态、组成和结构。循环伏安法和计时电流法被应用于研究不同的 Cu(2)O/Carbon Vulcan XC-72 样品在碱性介质中对葡萄糖氧化的电催化活性。'x70' 样品得到了最高的氧化电流密度和最低的氧化电位。该传感器的性能评估显示出宽线性范围可达 6mM，灵敏度为 629 μA cm(-2)mM(-1)，检测限为 2.4 μM。它对具有长期稳定性的抗坏血酸有很好的耐受性，这使得 Cu(2)O/Carbon Vulcan XC-72 成为一种有前途的葡萄糖传感器。
