Department of Cardiothoracic Surgery, Bristol Heart Institute, Bristol, UK.
Eur J Cardiothorac Surg. 2011 Oct;40(4):869-74. doi: 10.1016/j.ejcts.2011.01.010. Epub 2011 Feb 25.
Endovascular treatment is increasingly used to treat complicated aortic pathology. The aim of the study was to assess if compared with operative repair, thoracic endovascular repair of aorta (TEVAR) was associated with a cost benefit in management of diseases affecting the descending thoracic aorta. We also compared early and mid-term outcomes between the two groups.
Clinical characteristics, outcomes and hospitalisation costs of 84 consecutive patients undergoing intervention for conditions affecting the descending thoracic aorta were reviewed retrospectively. Hospitalisation costs were calculated from National Health Service (NHS) reference costs for staff time, consumables, transfusion and length of stay.
Apart from a higher frequency of acute type B dissection (16/45 vs 5/39, p = 0.047) in the TEVAR group, the baseline characteristics were similar. TEVAR was associated with significant reductions in morbidity (renal dysfunction 11 (31%) vs 5 (10%) p=0.025; in-hospital death 7 (20%) vs 3 (6%), p = 0.03; median intensive therapy unit (ITU) stay 6 (3-11) vs 1 (1-4), p < 0.0001). TEVAR was associated with significantly increased procedural costs (£2468 (€2961) vs £9581 (€11495) p ≤ 0.0001). This was chiefly attributable to the cost of endovascular stents. There was no significant difference in overall hospitalisation costs. TEVAR was associated with significantly lower freedom from death or re-operation (log rank p=0.048).
TEVAR is associated with reduced morbidity and mortality in the short term. However, no cost benefit was seen with TEVAR even in the short term. In the long term, due to increased risk of re-interventions TEVAR may actually prove to be a more expensive therapeutic option.
血管内治疗越来越多地用于治疗复杂的主动脉病变。本研究旨在评估与手术修复相比,胸主动脉腔内修复术(TEVAR)在治疗降主动脉疾病方面是否具有成本效益。我们还比较了两组患者的早期和中期结果。
回顾性分析了 84 例连续接受降主动脉疾病介入治疗的患者的临床特征、结果和住院费用。住院费用根据国民保健制度(NHS)工作人员时间、耗材、输血和住院时间的参考成本计算。
除 TEVAR 组急性 B 型夹层的发生率较高(16/45 比 5/39,p = 0.047)外,两组的基线特征相似。TEVAR 与发病率降低显著相关(肾功能不全 11 例(31%)比 5 例(10%),p = 0.025;院内死亡 7 例(20%)比 3 例(6%),p = 0.03;重症监护病房(ITU)中位停留时间 6(3-11)比 1(1-4),p < 0.0001)。TEVAR 与明显增加的手术费用相关(2468 英镑(2961 欧元)比 9581 英镑(11495 欧元),p ≤ 0.0001)。这主要归因于血管内支架的成本。总住院费用无显著差异。TEVAR 与死亡或再次手术的无复发率显著降低相关(对数秩检验 p = 0.048)。
TEVAR 与短期降低发病率和死亡率相关。然而,即使在短期内,TEVAR 也没有成本效益。从长远来看,由于再次介入的风险增加,TEVAR 实际上可能成为一种更昂贵的治疗选择。