人细小病毒 4（PARV4）的免疫球蛋白 G 和 M 抗体经常在 HIV-1 感染患者中被检测到。
Immunoglobulin G and M antibodies to human parvovirus 4 (PARV4) are frequently detected in patients with HIV-1 infection.
机构信息
Department of Internal Medicine, National Taiwan University Hospital, No. 7, Chung Shan South Road, 100 Taipei, Taiwan.
出版信息
J Clin Virol. 2011 May;51(1):64-7. doi: 10.1016/j.jcv.2011.01.017. Epub 2011 Feb 24.
BACKGROUND
The transmission routes of PARV4 are not completely understood. The first PARV4 serological study suggested that PARV4 is transmitted predominantly through parenteral route.
OBJECTIVES
To set up an immunoblot system for studying the epidemiology of PARV4 infection in HIV-1 infected patients in Taiwan.
STUDY DESIGN
Recombinant fusion proteins SUMOVP2 (a.a. 272-630 of PARV4 open reading frame 2) and SUMOVP3 (a.a. 604-914) were made and used as antigens in immunoblot. Plasma samples were from HIV-1 infected intravenous drug users IDU (69), homosexuals (66) and heterosexuals (68).
RESULTS
PARV4 IgG seropositive rate was 73.9%, 71.2% and 58.8%; IgM seropositive rate was 40.5%, 16.7% and 17.6% in IDUs, homosexuals and heterosexuals, respectively. Longitudinal samples were available from two homosexuals positive for IgM anti-PARV4, persistent IgM response was found over a period of 9 and 21 months, respectively.
CONCLUSIONS
PARV4 is a common viral infection in HIV-1 infected homosexuals and heterosexuals in Taiwan. The detection of IgM anti-PARV4 does not always suggest recent PARV4 infection.
背景
PARV4 的传播途径尚不完全清楚。第一项 PARV4 血清学研究表明，PARV4 主要通过 注射途径传播。
目的
建立免疫印迹系统，用于研究台湾地区 HIV-1 感染者中 PARV4 感染的流行病学。
研究设计
构建重组融合蛋白 SUMOVP2（PARV4 开放阅读框 2 的 a.a. 272-630）和 SUMOVP3（a.a. 604-914）作为免疫印迹的抗原。血浆样本来自 HIV-1 感染的静脉注射吸毒者（IDU，69 例）、同性恋者（66 例）和异性恋者（68 例）。
结果
IDU、同性恋者和异性恋者的 PARV4 IgG 血清阳性率分别为 73.9%、71.2%和 58.8%；IgM 血清阳性率分别为 40.5%、16.7%和 17.6%。两名同性恋者的 IgM 抗-PARV4 均为阳性，可获得其纵向样本，分别在 9 个月和 21 个月时发现持续的 IgM 反应。
结论
PARV4 是台湾地区 HIV-1 感染的同性恋者和异性恋者中常见的病毒感染。IgM 抗-PARV4 的检测并不总是提示近期的 PARV4 感染。
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