Department of Neurology, Kyoto University Graduate School of Medicine, Kyoto, Japan.
Clin Neurophysiol. 2011 Aug;122(8):1500-4. doi: 10.1016/j.clinph.2010.12.060. Epub 2011 Feb 25.
With advanced electroencephalography (EEG) technology, 'wideband EEG' ranging from slow shift to high frequency oscillation (HFO) is clinically available to study human epileptogenesis. The purpose of our study is to clarify the relationship between slow shift, HFO and conventional electrocorticographic (ECoG) change.
A patient with right temporal lobe epilepsy who underwent presurgical evaluation with subdural electrodes was studied. Slow shift and HFO were evaluated in 16 habitual seizures with wideband EEG technique (bandpass filter of 0.016-600 Hz).
Upon seizure occurrence in wideband ECoG, negative slow shifts coexisted with HFO (100-300 Hz) in the ictal onset zone in all investigated seizures. The former always preceded HFO and conventional initial EEG changes by mean value of 1.6 and 20.4s, respectively. The slow shifts and HFOs were observed only in the restricted ictal onset zone.
In this particular patient, wideband EEG could delineate both ictal slow shift and HFO to define ictal onset zone, and the earliest occurrence of slow shifts may suggest an early role of glia in slow EEG shift generation than neurons.
The time difference of the onset between ictal HFO and slow shift may help to understand epileptogenesis.
随着先进的脑电图（EEG）技术的发展，从慢移到高频振荡（HFO）的“宽带 EEG”可用于临床研究人类癫痫发生。我们研究的目的是阐明慢移、HFO 与常规皮质脑电图（ECoG）变化之间的关系。
研究了一名接受颅内电极术前评估的右侧颞叶癫痫患者。使用宽带 EEG 技术（0.016-600 Hz 带通滤波器）评估了 16 例习惯性癫痫发作中的慢移和 HFO。
在宽带 ECoG 中发生癫痫发作时，所有研究的癫痫发作中，在发作起始区都存在负性慢移与 HFO（100-300 Hz）共存。前者总是先于 HFO 和常规初始 EEG 变化出现，平均值分别为 1.6 和 20.4s。慢移和 HFO 仅在有限的发作起始区观察到。
在这个特定的患者中，宽带 EEG 可以描绘发作性慢移和 HFO，以定义发作起始区，并且慢移的最早出现可能表明胶质细胞在慢 EEG 移产生中的作用比神经元更早。
发作性 HFO 和慢移之间的起始时间差异可能有助于理解癫痫发生。
