Müller F, Rollag H, Frøland S S
Kaptein Wilhelmsen og Frues Institute of Bacteriology, University of Oslo, Rikshospitalet, Norway.
J Biol Regul Homeost Agents. 1990 Jul-Sep;4(3):93-7.
In the present paper, we have studied the effects of interferon (IFN) -alpha and IFN-beta on the oxidative burst (OB) responses in monocytes and monocyte-derived macrophages from patients with a relatively early phase of HIV infection. We found that in monocytes from patients with HIV infection, the defective OB response could be partially restored by pretreatment with IFN-beta when the cells were challenged with zymosan. No such stimulatory effect was seen in the control groups. In monocyte-derived macrophages, both IFN-alpha and IFN-beta stimulated the phorbol myristate acetate (PMA) induced OB response in the patient group as well as in the blood donor control group. Generation of an OB is an important part of the antimicrobial defence of mononuclear phagocytes. The positive effects of IFN on the OB responses of monocytes and macrophages from patients with HIV infection may be of importance when IFNs are considered in the treatment of HIV-related disease.
在本论文中，我们研究了α干扰素（IFN）和β干扰素对处于HIV感染相对早期阶段患者的单核细胞及单核细胞衍生巨噬细胞中氧化爆发（OB）反应的影响。我们发现，在HIV感染患者的单核细胞中，当用酵母聚糖刺激细胞时，β干扰素预处理可部分恢复有缺陷的OB反应。对照组未观察到这种刺激作用。在单核细胞衍生巨噬细胞中，α干扰素和β干扰素均刺激了患者组以及献血者对照组中佛波酯肉豆蔻酸酯乙酸酯（PMA）诱导的OB反应。OB的产生是单核吞噬细胞抗菌防御的重要组成部分。当考虑将干扰素用于治疗HIV相关疾病时，干扰素对HIV感染患者单核细胞和巨噬细胞OB反应的积极作用可能具有重要意义。
