激活素受体样激酶与胰岛素基因。

Activin receptor-like kinase and the insulin gene.

机构信息

Department of Diabetes and Clinical Nutrition, Kyoto University Graduate School of Medicine, Kyoto, Japan.

出版信息

Vitam Horm. 2011;85:1-27. doi: 10.1016/B978-0-12-385961-7.00001-9.

Abstract

The biological responses of the transforming growth factor-β (TGF-β) superfamily, which includes Activins and Nodal, are induced by activation of a receptor complex and Smads. A type I receptor, which is a component of the complex, is known as an activin receptor-like kinase (ALK); currently seven ALKs (ALK1-ALK7) have been identified in humans. Activins signaling, which is mediated by ALK4 and 7 together with ActRIIA and IIB, plays a critical role in glucose-stimulated insulin secretion, development/neogenesis, and glucose homeostatic control of pancreatic endocrine cells; the insulin gene is regulated by these signaling pathways via ALK7, which is a receptor for Activins AB and B and Nodal. This review discusses signal transduction of ALKs in pancreatic endocrine cells and the role of ALKs in insulin gene regulation.

摘要

转化生长因子-β（TGF-β）超家族的生物学反应包括激活素和 Nodal，由受体复合物和 Smads 的激活诱导。受体复合物的一个组成部分是 I 型受体，称为激活素受体样激酶（ALK）；目前已在人类中鉴定出七种 ALKs（ALK1-ALK7）。ALK4 和 7 与 ActRIIA 和 IIB 共同介导的激活素信号传导在葡萄糖刺激的胰岛素分泌、发育/新生和胰腺内分泌细胞的葡萄糖稳态控制中发挥关键作用；胰岛素基因通过这些信号通路通过 ALK7 进行调节，ALK7 是激活素 AB 和 B 和 Nodal 的受体。这篇综述讨论了 ALKs 在胰腺内分泌细胞中的信号转导以及 ALKs 在胰岛素基因调节中的作用。