Division of Infectious Diseases, Department of Internal Medicine, and Research Center for Resistant Cells, Chosun University College of Medicine, Gwangju, Republic of Korea.
Diagn Microbiol Infect Dis. 2011 Mar;69(3):271-4. doi: 10.1016/j.diagmicrobio.2010.10.005.
We report on a scrub typhus patient who contracted meningoencephalitis during doxycycline administration. This is the first case of scrub typhus in which doxycycline concentrations were measured in serum and cerebrospinal fluid. Clinicians should be alerted to the possibility that meningoencephalitis can occur because of inadequate maintenance of serum doxycycline level caused by antacids administered along with doxycycline.
我们报告了一例在使用强力霉素治疗期间发生脑膜脑炎的恙虫病患者。这是首例检测到血清和脑脊液中强力霉素浓度的恙虫病病例。临床医生应该警惕因同时使用强力霉素和抗酸剂而导致血清强力霉素水平维持不足，从而可能发生脑膜脑炎的可能性。
