Sans Capdevila Oscar, Wienberg Peter, Haag Oliver, Cols María
Unidad Funcional de SAHS, Hospital Sant Joan de Déu, Barcelona, España.
Acta Otorrinolaringol Esp. 2010 Dec;61 Suppl 1:26-32. doi: 10.1016/S0001-6519(10)71242-5.
Sleep-related respiratory disorders in children, especially childhood sleep apnea-hypopnea syndrome, are associated with a wide range of comorbidities affecting the central nervous system, cardiovascular and metabolic systems, and growth. The two most important factors contributing to the physiopathology of this disorder are intermittent hypoxia and sleep fragmentation, which seem to cause the systemic inflammatory response resulting in these end-organ consequences.
儿童睡眠相关呼吸障碍,尤其是儿童睡眠呼吸暂停低通气综合征,与一系列影响中枢神经系统、心血管和代谢系统以及生长发育的合并症相关。导致这种疾病病理生理的两个最重要因素是间歇性缺氧和睡眠片段化,它们似乎会引发全身炎症反应,从而导致这些终末器官的后果。