Martín B, Fernández B, Domínguez F J
Sección de Neumología, Hospital de Navarra, Pamplona.
An Sist Sanit Navar. 2007;30 Suppl 1:89-95.
Sleep apnea-hypopnea syndrome is characterised by daytime sleepiness, cognitive-behavioural, respiratory, cardiac, metabolic or inflammatory disorders, secondary to repeated obstruction of the upper airway during sleep. Numerous studies have shown that SAHS is associated with the presence of arterial hypertension and the development of cardiovascular diseases. Similarly, there is an excess of mortality associated with SAHS. An increase in the activity of the sympathetic nervous system and endothelial dysfunction are considered as mediating mechanisms, together with phenomena of oxidative stress, platelet aggregation and thrombosis.
睡眠呼吸暂停低通气综合征的特征是白天嗜睡、认知行为、呼吸、心脏、代谢或炎症紊乱，这些是睡眠期间上呼吸道反复阻塞继发的结果。大量研究表明，睡眠呼吸暂停低通气综合征与动脉高血压的存在以及心血管疾病的发生有关。同样，睡眠呼吸暂停低通气综合征也与死亡率过高有关。交感神经系统活性增加和内皮功能障碍被认为是介导机制，同时还有氧化应激、血小板聚集和血栓形成等现象。
