Jajić I
Klinika za fizikalnu medicinu i rehabilitaciju Medicinskog fakulteta Sveucilista u nastavnoj bazi Klinicke bolnice Dr. Mladen Stojanović Zagreb.
Reumatizam. 1990;37(1-6):3-9.
The antiinflammatory drugs are broadly used also in the treatment of inflammatory and degenerative rheumatic diseases relating to the treatment of extraarticular rheumatism. It has been held that they have an effect in rheumatic diseases even by means of the inhibition of prostaglandins synthesis. Later it was evidented that all drugs coming from that group cause a numerous side-effects particularly in gastrointestinal system, usually relating to those caming a strong inhibition of prostaglandin synthesis. Some of them cause a selective inhibition of prostaglandin synthesis especially in stomach and kidneys. The appearance of side-effects in gastrointestinal system with patients taking these drugs for a longer period of time could be prevented by a careful choice of their usage. It has been evidented that misoprostol strongly effect the prevention of stomach lesions and duodenum enabling so the usage of non-steroidal antiinflammatory drugs over a longer period of time.
抗炎药物还广泛用于治疗与关节外风湿病治疗相关的炎性和退行性风湿性疾病。人们认为，它们通过抑制前列腺素合成对风湿性疾病产生作用。后来发现，该类所有药物都会引起大量副作用，尤其是在胃肠道系统，通常与那些强烈抑制前列腺素合成的药物有关。其中一些药物会对前列腺素合成产生选择性抑制，尤其是在胃和肾脏。通过谨慎选择用药方式，可以预防长期服用这些药物的患者在胃肠道系统出现副作用。已证实米索前列醇对预防胃部病变和十二指肠病变有显著效果，从而使非甾体抗炎药能够长期使用。
