Department of Neurology, University Hospital Muenster, Germany.
Seizure. 2011 Jun;20(5):428-30. doi: 10.1016/j.seizure.2011.01.017. Epub 2011 Feb 26.
Status epilepticus (SE) is a frequent neurological emergency requiring immediate treatment. Therapy usually requires intravenous anticonvulsive medication. Lacosamide is a novel anticonvulsant drug that is available as infusion solution. We describe seven patients with focal SE who were treated with intravenous Lacosamide. All patients in our case series were unsuccessfully treated with other antiepileptic drugs before Lacosamide i.v. was added. In all cases, SE was terminated within 24 h after Lacosamide. There were no serious side effects or adverse events attributable to Lacosamide i.v. Our data suggest that Lacosamide might be an effective add-on treatment, if standard drugs fail or are unsuitable.
癫痫持续状态（SE）是一种需要立即治疗的常见神经系统急症。治疗通常需要静脉用抗惊厥药物。拉考沙胺是一种新型抗惊厥药物，可作为输注溶液使用。我们描述了 7 例局灶性 SE 患者，他们接受了静脉用拉考沙胺治疗。在使用静脉用拉考沙胺之前，我们病例系列中的所有患者均对其他抗癫痫药物治疗无效。在所有情况下，在使用拉考沙胺后 24 小时内 SE 均得到终止。没有与静脉用拉考沙胺相关的严重副作用或不良事件。我们的数据表明，如果标准药物无效或不适用，拉考沙胺可能是一种有效的附加治疗方法。
