Malaria Programme, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, CB10 1SA, UK.
Trends Parasitol. 2011 May;27(5):222-9. doi: 10.1016/j.pt.2011.01.006. Epub 2011 Feb 25.
Recent studies of captive and wild-living apes in Africa have uncovered evidence of numerous new Plasmodium species, one of which was identified as the immediate precursor of human Plasmodium falciparum. These findings raise the question whether wild apes could be a recurrent source of Plasmodium infections in humans. This question is not new, but was the subject of intense investigation by researchers in the first half of the last century. Re-examination of their work in the context of recent molecular findings provides a new framework to understand the diversity of Plasmodium species and to assess the risk of future cross-species transmissions to humans in the context of proposed malaria eradication programs.
最近对非洲圈养和野生猿类的研究发现了许多新的疟原虫物种的证据，其中一种被确定为人类疟原虫 falciparum 的直接前体。这些发现提出了一个问题，即野生猿类是否可能是人类疟原虫感染的反复来源。这个问题并不新鲜，但在上个世纪前半叶，研究人员对此进行了深入调查。在最近的分子发现的背景下重新审查他们的工作，为理解疟原虫物种的多样性以及评估在拟议的消除疟疾计划背景下未来跨物种传播给人类的风险提供了一个新的框架。
