McGill University, Montreal, Quebec, Canada.
Epilepsy Behav. 2011 Mar;20(3):518-23. doi: 10.1016/j.yebeh.2011.01.002. Epub 2011 Feb 26.
Remembering meaningful information is an important component of verbal memory. However, findings from existing story memory tests have been mixed in patients with temporal lobe epilepsy (TLE). We developed a test, the Story Learning and Memory (SLAM) test, in which a story is presented repeatedly until a performance criterion is reached, and verbatim recall is obtained only once, after a delay. In Study 1 we demonstrated a significant learning deficit in patients with left, but not right, TLE, and they were further impaired in retention of the story despite having learned it to the same criterion as subjects with right TLE and healthy subjects. These deficits remained confined to patients with left TLE after surgery. For clinical use we developed the SLAM in three versions in two languages; in studies 2 and 3 we tested and proved their equivalence.
记住有意义的信息是言语记忆的一个重要组成部分。然而,在颞叶癫痫(TLE)患者中,现有故事记忆测试的结果喜忧参半。我们开发了一种测试,即故事学习和记忆(SLAM)测试,在该测试中,一个故事会被反复呈现,直到达到一个表现标准,并且在延迟后仅获得一次逐字回忆。在研究 1 中,我们在左颞叶癫痫患者中证明了明显的学习缺陷,但在右颞叶癫痫患者和健康受试者中,他们在保留故事方面的缺陷更为明显,尽管他们已经达到了与右颞叶癫痫患者和健康受试者相同的标准。这些缺陷在手术后仍然局限于左颞叶癫痫患者。为了临床应用,我们用两种语言开发了三种版本的 SLAM;在研究 2 和 3 中,我们对其进行了测试并证明了它们的等效性。