Fang Qi, Wang Xue-fen
Department of Breast Surgery, Third Affiliated Hospital of Suzhou University, Changzhou 213000, China.
Nan Fang Yi Ke Da Xue Xue Bao. 2011 Feb;31(2):380-2.
To investigate the relation of CerbB-2 with Ki-67 and P53 expressions in hormone-independent breast cancer.
A total of 180 patients with breast cancer were examined for the positivity to estrogen receptor (ER) and progesterone receptor (PR), and subsequently divided into hormone-dependent group (positive for both ER and PR) and hormone-independent group (negative for both). CerbB-2, Ki-67 and P53 expressions were detected in these patients using an improved Envision immunohistochemical staining with the corresponding antibodies. Twenty-nine patients without definite immunohistochemical results of C-erbB-2 were excluded from further analysis. The 51 hormone-independent and 100 hormone-dependent cases were analyzed for the correlation of CerbB-2 to Ki-67 and P53 expressions.
In hormone-independent cases negative for CerbB-2, Ki-67 and P53 expressions were significantly higher than that in hormone-dependent CerbB-2-negative cases (P<0.05), but in CerbB-2-positive cases, their expressions showed no significant differences (P>0.05) with respect to hormonal dependence.
In hormone-independent CerbB-2-negative cases, the tumor cells show a higher proliferative activity and P53 expression than those in hormone-dependent cases, which can be an important reason for the high malignancy and poor prognosis of hormone-independent breast cancer negative for CerbB-2.
探讨激素非依赖性乳腺癌中C-erbB-2与Ki-67及P53表达的关系。
对180例乳腺癌患者检测雌激素受体（ER）和孕激素受体（PR）的阳性情况，随后分为激素依赖性组（ER和PR均阳性）和激素非依赖性组（ER和PR均阴性）。采用改良的Envision免疫组化染色法及相应抗体检测这些患者的C-erbB-2、Ki-67和P53表达。29例C-erbB-2免疫组化结果不明确的患者被排除在进一步分析之外。对51例激素非依赖性和100例激素依赖性病例分析C-erbB-2与Ki-67及P53表达的相关性。
在激素非依赖性病例中，C-erbB-2阴性者的Ki-67和P53表达显著高于激素依赖性C-erbB-2阴性病例（P<0.05），但在C-erbB-2阳性病例中，其表达在激素依赖性方面无显著差异（P>0.05）。
在激素非依赖性C-erbB-2阴性病例中，肿瘤细胞的增殖活性和P53表达高于激素依赖性病例，这可能是激素非依赖性C-erbB-2阴性乳腺癌恶性程度高、预后差的重要原因。
