四嗪卟啉：肿瘤定位的氧化还原活性扩展卟啉。
Texaphyrins: tumor localizing redox active expanded porphyrins.
机构信息
Department of Chemistry and Biochemistry, The University of Texas at Austin, Austin, TX 78712-0165, USA.
出版信息
Anticancer Agents Med Chem. 2011 Feb;11(2):222-32. doi: 10.2174/187152011795255894.
Abstract
Texaphyrins, a class of tumor selective expanded porphyrins capable of coordinating large metals, have been found to act as redox mediators within biological systems. This review summarizes studies involving their experimental use in cancer chemotherapy. Mechanistic insights involving their presumed mode of action are also described, as well as certain structure activity relationships. Finally, newer texaphyrin-based applications associated with targeted drug delivery are presented.
摘要
卟啉类化合物是一类能够与大金属配位的肿瘤选择性扩展卟啉，已被发现可在生物体系中充当氧化还原介质。本综述总结了涉及它们在癌症化疗中实际应用的研究。还描述了涉及它们假定作用模式的机制见解以及某些结构活性关系。最后，提出了与靶向药物递送相关的新型基于卟啉的应用。
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