Shimahara M, Ono K, Hashiguchi N, Senda J, Shimamura T, Honke T, Higashisawa S
Department of Oral Surgery, Osaka Medical College, Japan.
Bull Osaka Med Coll. 1990 Nov;36(1-2):93-102.
In the present study, intermaxillary fixation for a period of 1 or 2 weeks after excision of the articular disc was administered to maturing rats. After removal of the fixation, the animals were allowed unrestricted mandibular movement. Histological observations were made at the postoperative 3rd month in those rats which demonstrated normal occlusion. As a result, it was found that the normal articular disc did not regenerate. However, in the articular cavity, both connective tissue and articular disc-like structures were found. The major changes in the mandibular fossa were tylosis of the outer fibrous layer of the fossa and an accompanying shallowing tendency. The major changes in the condyle were tylosis and morphological deformation of the fibrous layer of the parietal region. The deformation was mainly manifested by a fan-shaped hypertrophy. In the cases in which neither connective tissue nor articular disc-like structures were present in the articular cavity, changes in the mandibular fossa and condyle were remarkable. The appearance of the articular disc-like structure was more frequent in cases with 2-week intermaxillary fixation than in those with 1-week fixation.
在本研究中，对成熟大鼠在切除关节盘后进行1或2周的颌间固定。去除固定后，让动物下颌自由活动。对术后3个月咬合正常的大鼠进行组织学观察。结果发现，正常关节盘未再生。然而，在关节腔内发现了结缔组织和类关节盘结构。下颌窝的主要变化是窝外纤维层的纤维性增厚及随之而来的变浅趋势。髁突的主要变化是顶区纤维层的纤维性增厚和形态变形。变形主要表现为扇形肥大。在关节腔内既无结缔组织也无类关节盘结构的病例中，下颌窝和髁突的变化显著。与1周颌间固定的病例相比，2周颌间固定的病例中类关节盘结构的出现更为频繁。
