Onat T, Ahunbay G
Department of Pediatrics, Istanbul University Cerrahpaşa Faculty of Medicine, Turkey.
Turk J Pediatr. 1990 Oct-Dec;32(4):249-58.
Thirty-one patients with acute rheumatic carditis associated with aortic (AR) and mitral regurgitation (MR) who received corticosteroid anti-inflammatory therapy for an average of nine weeks were followed up for 332 patient-years (mean: 10.71 years). The age of onset was 9.34 (1 SD = +/- 1.94) years. The patients were classified according to degree of left ventricular volume overloading (LVH), duration of pre-treatment interval and regularity of penicillin prophylaxis. The probability of the yearly disappearance of MR, AR and both lesions were calculated for the total group and in relation to affecting subgroups. The mean yearly rate of disappearance of AR was 2 percent after a 10 percent probability in the first year. This rate was 6.83 percent per year for MR, and it increased to 10.15 percent per year in the patients in whom therapy was initiated in less than three weeks, and decreased to 3.14 percent in the patients in whom therapy was initiated after three weeks. The disappearance of both AR and MR was observed in only two patients (about 1% per year); MS developed in two patients (6.45%) and the mortality rate was 3.2 percent in 332 patient-years (0.0001/year).
31例患有急性风湿性心脏炎并伴有主动脉反流（AR）和二尖瓣反流（MR）的患者接受了平均为期9周的皮质类固醇抗炎治疗，随访了332患者年（平均：10.71年）。发病年龄为9.34（1标准差=±1.94）岁。根据左心室容量超负荷程度（LVH）、治疗前间隔时间和青霉素预防的规律性对患者进行分类。计算了整个组以及相关亚组中MR、AR和两种病变每年消失的概率。AR在第一年有10%的概率后，每年的平均消失率为2%。MR的年消失率为6.83%，在治疗开始少于三周的患者中升至每年10.15%，在治疗开始三周后开始治疗的患者中降至3.14%。仅在两名患者中观察到AR和MR均消失（每年约1%）；两名患者（6.45%）出现二尖瓣狭窄，在332患者年中的死亡率为3.2%（每年0.0001）。
