Hata Kenji, Nakanishi Masako, Morita Yoshihiro, Yoneda Toshiyuki
Department of Biochemistry, Osaka University Graduate School of Dentistry.
Clin Calcium. 2011 Mar;21(3):349-56.
Bone is one of the most preferential metastatic target sites for cancers. However, based on the anatomical structure of the vascular system, bone is not recognized as a preferential metastatic target. Therefore, the biological crosstalk between metastatic cancer cells and bone is critical to the development and progression of bone metastases. Bone microenvironments possess unique biological features characterized by abundant growth factors and diverse cellular network including osteoblasts, osteoclasts and hematopietic cells. Cancers develop bone metastases by utilizing these unique bone environments for colonization and bone destruction. Better understandings of precise molecular mechanisms underlying cancer and bone crosstalk would contribute to the development of new therapeutic approaches for the treatment of bone metastasis at molecular levels.
骨骼是癌症最优先转移的靶位点之一。然而，基于血管系统的解剖结构，骨骼并不被认为是优先转移的靶标。因此，转移性癌细胞与骨骼之间的生物学相互作用对于骨转移的发生和发展至关重要。骨微环境具有独特的生物学特征，其特点是生长因子丰富，细胞网络多样，包括成骨细胞、破骨细胞和造血细胞。癌症通过利用这些独特的骨环境进行定植和骨破坏来发生骨转移。更好地理解癌症与骨骼相互作用背后的精确分子机制，将有助于在分子水平上开发治疗骨转移的新治疗方法。
