Richard N R, Lambert R W, Anderson J A
National Vision Research Institute, San Diego, CA.
Methods Mol Med. 1996;2:489-501. doi: 10.1385/0-89603-335-X:489.
Keratocytes, or cornea1 fibroblasts, are the primary cell type of the cornea1 stroma. They lie between and are oriented parallel to the orthogonally arranged collagen lamellae, forming a continuous interconnecting cellular network that has been hypothesized to transmit information throughout the cornea concerning the status of the tissue (1). Under normal conditions, the keratocyte in the adult cornea is a relatively quiescent cell. However, in the event of a cornea1 injury or trauma, the keratocytes near the injured area differentiate into active, synthesizing cells and rapidly replace damaged stromal matrix (3, 3).
角膜细胞,即角膜成纤维细胞,是角膜基质的主要细胞类型。它们位于正交排列的胶原板层之间,并与其平行排列,形成一个连续的相互连接的细胞网络,据推测该网络可在整个角膜中传递有关组织状态的信息(1)。在正常情况下,成年角膜中的角膜细胞是相对静止的细胞。然而,在角膜受到损伤或创伤时,损伤区域附近的角膜细胞会分化为活跃的合成细胞,并迅速替代受损的基质(3,3)。