Krzymowski T, Kotwica J, Okrasa S, Doboszyńska T, Zieçik A
J Reprod Fertil. 1978 Sep;54(1):21-7. doi: 10.1530/jrf.0.0540021.
Prostaglandin F-2alpha (1.5 mg over 10 h) was infused into the anterior uterine vein of pigs on Days 6, 8, 10, 12, 14 and 15 of the oestrous cycle. At each stage of the cycle PGF-2alpha suppressed luteal function although the fall in progesterone secretion was much greater and statistically significant when the infusion was performed on Days 12, 14 and 15 of the cycle than on Days 6, 8 and 10. The concentrations of cAMP was depressed on Days 15 and 17 and fatty degeneration of luteal cells on Days 6--8 or 14 was more pronounced in the ovary ipsilateral to the PGF-2alpha infusion than in the contralateral ovary. The results are compatible with the local perfusion of PGF-2alpha from the anterior uterine vein to the ipsilateral ovary, but a systemic effect was also apparent.
在发情周期的第6、8、10、12、14和15天，将前列腺素F-2α（1.5毫克，持续10小时）注入猪的子宫前静脉。在周期的每个阶段，PGF-2α均抑制黄体功能，尽管当在周期的第12、14和15天进行输注时，孕酮分泌的下降比在第6、8和10天进行输注时更大且具有统计学意义。在第15和17天，cAMP浓度降低，在第6-8天或第14天，PGF-2α输注同侧卵巢的黄体细胞脂肪变性比 contralateral 卵巢更明显。结果与PGF-2α从子宫前静脉向同侧卵巢的局部灌注相符，但全身作用也很明显。
